Pleiotropy in complex traits: challenges and strategies (Q28390545)

5

object named as

Jordan W Smoller

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author name string

Nadia Solovieff

1

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Phil H Lee

3

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Shaun M Purcell

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

4

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language of work or name

English

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publication date

July 2013

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published in

Nature Reviews Genetics

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volume

14

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issue

7

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page(s)

483-95

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cites work

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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

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20 March 2017

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Galectin-3 regulates myofibroblast activation and hepatic fibrosis

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

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7 April 2017

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One Hundred Years of Pleiotropy: A Retrospective

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New approaches to population stratification in genome-wide association studies

29 September 2017

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Architecture of inherited susceptibility to common cancer

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29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Validating, augmenting and refining genome-wide association signals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Detecting shared pathogenesis from the shared genetics of immune-related diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Epidemiology of autoimmune diseases in Denmark

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Mechano-transduction mediated secretion and uptake of galectin-3 in breast carcinoma cells: implications in the extracellular functions of the lectin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Alterations in galectin-3 expression and distribution correlate with breast cancer progression: functional analysis of galectin-3 in breast epithelial-endothelial interactions.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Down-regulation of galectin-3 suppresses tumorigenicity of human breast carcinoma cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

High frequency targeting of genes to specific sites in the mammalian genome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Using multiple genetic variants as instrumental variables for modifiable risk factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Procedures for comparing samples with multiple endpoints

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Major depression and generalized anxiety disorder. Same genes, (partly) different environments?

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Biorepositories: Building better biobanks.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Modifiers and subtype-specific analyses in whole-genome association studies: a likelihood framework

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

A multivariate test of association

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Pleiotropy and principal components of heritability combine to increase power for association analysis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Combining dependent tests for linkage or association across multiple phenotypic traits

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

A multivariate family-based association test using generalized estimating equations: FBAT-GEE.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Implications of comorbidity and ascertainment bias for identifying disease genes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104202

Lyp breakdown and autoimmunity

27 November 2018

1 reference

31 March 2020

When the smoke clears ..

1 reference

A principal-components approach based on heritability for combining phenotype information

31 March 2020

1 reference

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

31 March 2020

1 reference

Limitations of the Application of Fourfold Table Analysis to Hospital Data

31 March 2020

2 references

https://pubmed.ncbi.nlm.nih.gov/23752797

31 March 2020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3461

1 reference

Dimensions Publication ID

1022623339

0 references

1 reference

1 reference

PubMed publication ID

23752797

1 reference