HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction (Q28383407)

2

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10 June 2020

author name string

Hyo Jin Kang

1

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10 June 2020

Young Bin Hong

3

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10 June 2020

Hee Jeong Kim

4

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10 June 2020

Young-Joo Jang

5

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10 June 2020

Yeon-Sun Seong

6

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10 June 2020

Insoo Bae

7

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10 June 2020

language of work or name

English

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publication date

3 December 2014

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published in

Scientific Reports

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10 June 2020

volume

4

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10 June 2020

page(s)

7201

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Creative Commons Attribution 4.0 International

10 June 2020

copyright license

start time

3 December 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine

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Role of Nrf2 in oxidative stress and toxicity

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20 March 2017

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Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3

20 March 2017

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

20 March 2017

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Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

20 March 2017

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Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

20 March 2017

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Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

20 March 2017

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Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation

7 April 2017

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BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

29 September 2017

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HER2-targeted therapy in breast cancer: a systematic review of neoadjuvant trials

29 September 2017

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Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination

29 September 2017

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The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

29 September 2017

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Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

29 September 2017

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The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer

29 September 2017

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Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis

29 September 2017

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NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity

29 September 2017

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PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

29 September 2017

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Taxane resistance in breast cancer: a closed HER2 circuit?

29 September 2017

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Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

29 September 2017

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Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein

29 September 2017

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Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells

29 September 2017

1 reference

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Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

29 September 2017

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SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

29 September 2017

1 reference

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Mechanisms of Endocrine Resistance in Breast Cancer

29 September 2017

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CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation

29 September 2017

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Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells

29 September 2017

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Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252900

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

29 September 2017

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The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis

29 September 2017

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The dark side of EGFP: defective polyubiquitination

29 September 2017

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Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252900

BRCA1 induces antioxidant gene expression and resistance to oxidative stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252900

Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252900

Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4252900

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/SREP07201

Characterization of a novel tripartite nuclear localization sequence in the EGFR family

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/SREP07201

Effective intravenous therapy of murine pulmonary metastases with an oncolytic herpes virus expressing interleukin 12

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/SREP07201

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SREP07201

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25467193 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25467193 AND SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

25467193

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25467193 AND SRC:MED&resulttype=core&format=json