Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations (Q28368072)

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Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies

20 March 2017

1 reference

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SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures

29 September 2017

1 reference

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Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates

29 September 2017

1 reference

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Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions

29 September 2017

1 reference

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Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin.

2 June 2018

1 reference

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Homeostasis of Oxygen Supply in Liver and Kidney

2 June 2018

1 reference

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Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity

2 June 2018

1 reference

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In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent.

2 June 2018

1 reference

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Flavonoids are scavengers of superoxide anions

2 June 2018

1 reference

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Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines

2 June 2018

1 reference

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1-bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes

2 June 2018

1 reference

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Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

2 June 2018

1 reference

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Role of cytochrome P-450IIE1 in N-nitroso-N-methylaniline induced hepatocyte cytotoxicity

2 June 2018

1 reference

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The catecholic metal sequestering agent 1,2-dihydroxybenzene-3, 5-disulfonate confers protection against oxidative cell damage

2 June 2018

1 reference

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Chloroacetaldehyde-induced hepatocyte cytotoxicity. Mechanisms for cytoprotection.

2 June 2018

1 reference

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Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical

27 November 2018

1 reference

12 December 2020

Acute lesions in rats caused by 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) or nitromin: a comparison with rates of reduction in microsomal systems from target organs

1 reference

12 December 2020

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver

1 reference

12 December 2020

Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075)

1 reference

12 December 2020

Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes

1 reference

12 December 2020

Cytochrome P450 2B1-mediated one-electron reduction of adriamycin: a study with rat liver microsomes and purified enzymes

1 reference

12 December 2020

Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase

1 reference

12 December 2020

Isolation and use of liver cells

1 reference

12 December 2020

High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides

1 reference

12 December 2020

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

1 reference

12 December 2020

Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)

1 reference

12 December 2020

Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233

1 reference

12 December 2020

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

1 reference

12 December 2020

Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin

1 reference

12 December 2020