A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts (Q28363033)

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2 December 2019

title

A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts (English)

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2 December 2019

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ChEBI release 2020-05-28

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Christopher S. Williams

1

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2 December 2019

author name string

H Sheng

2

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2 December 2019

J A Brockman

3

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2 December 2019

R Armandla

4

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2 December 2019

J Shao

5

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2 December 2019

M K Washington

6

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2 December 2019

A G Elkahloun

7

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2 December 2019

R N DuBois

8

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2 December 2019

language of work or name

English

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publication date

1 September 2001

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2 December 2019

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2 December 2019

volume

3

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2 December 2019

issue

5

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2 December 2019

page(s)

428-436

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Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells

2 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Meloxicam inhibits the growth of colorectal cancer cells

7 April 2017

1 reference

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NSAIDs, gastrointestinal injury, and cytoprotection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2.

29 September 2017

1 reference

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Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis

29 September 2017

1 reference

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Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Aspirin use and reduced risk of fatal colon cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Sulindac causes rapid regression of preexisting tumors in Min/ mice independent of prostaglandin biosynthesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Sulindac suppresses tumorigenesis in the Min mouse.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1506203

Aspirin use and the risk for colorectal cancer and adenoma in male health professionals

27 November 2018

1 reference

12 December 2020

Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis

1 reference

12 December 2020

Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis

1 reference

12 December 2020

Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion

1 reference

12 December 2020

Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation

1 reference

12 December 2020

The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.NEO.7900177

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11687954 AND SRC:MED&resulttype=core&format=json

2 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11687954 AND SRC:MED&resulttype=core&format=json

2 December 2019

PubMed publication ID

11687954

1 reference