BACE1 expression and activity: relevance in Alzheimer's disease (Q28307707)

Europe PubMed Central

title

BACE1 expression and activity: relevance in Alzheimer's disease (English)

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Marija Mihailovich

4

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Daniele Zacchetti

object named as

Daniele Zacchetti

1

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Evelina Chieregatti

object named as

Evelina Chieregatti

2

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author name string

Barbara Bettegazzi

3

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Vitor Lino Sousa

5

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Fabio Grohovaz

6

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Jacopo Meldolesi

Neurodegenerative Diseases

7

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language of work or name

English

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publication date

2007

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published in

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volume

4

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issue

2-3

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page(s)

117-26

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cites work

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

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Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

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The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

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The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

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BACE2 functions as an alternative alpha-secretase in cells

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Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells

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Neuronal membrane cholesterol loss enhances amyloid peptide generation

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Phosphorylation regulates intracellular trafficking of beta-secretase

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