Novel α-MSH analog causes weight loss in obese rats and minipigs and improves insulin sensitivity (Q28301492)

2

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Cecilia Nilsson

3

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Kirsten Dahl

4

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Birgitte S Wulff

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility

5

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language of work or name

English

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publication date

February 2014

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published in

Journal of Endocrinology

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volume

220

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issue

2

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page(s)

97-107

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cites work

1 reference

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Central melanocortin receptors regulate insulin action

20 March 2017

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A frameshift mutation in human MC4R is associated with a dominant form of obesity

20 March 2017

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A frameshift mutation in MC4R associated with dominantly inherited human obesity

20 March 2017

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

20 March 2017

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

20 March 2017

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Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat

20 March 2017

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Brown adipose tissue: function and physiological significance

20 March 2017

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Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques

7 April 2017

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A review of unmet needs in obesity management

29 September 2017

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Targeting thermogenesis and related pathways in anti-obesity drug discovery

29 September 2017

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Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice.

29 September 2017

1 reference

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Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways

29 September 2017

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Small molecule ligands of the human melanocortin-4 receptor

29 September 2017

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The uncoupling protein 1 gene (UCP1) is disrupted in the pig lineage: a genetic explanation for poor thermoregulation in piglets

29 September 2017

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The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

29 September 2017

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New aspects on the melanocortins and their receptors

29 September 2017

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Insulin resistance and human disease: a short history

29 September 2017

1 reference

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Induction of sexual excitement with intraventricular ACTH; permissive role of testosterone in the male rabbit

29 September 2017

1 reference

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Corticotropin inhibits food intake in rats.

2 June 2018

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Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues

2 June 2018

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Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome.

27 November 2018

1 reference

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Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet

27 November 2018

1 reference

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Oral administration of glucose promotes intracellular partitioning of fatty acid toward storage in white but not in red muscle

27 November 2018

1 reference

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Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats

27 November 2018

1 reference

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Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice

27 November 2018

1 reference

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The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

27 November 2018

1 reference

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Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression

27 November 2018

1 reference

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Effect of alpha- and betamelanocyte stimulating hormones on the skin colour of man.

27 November 2018

1 reference

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Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

27 November 2018

1 reference

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Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity

27 November 2018

1 reference

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The central melanocortin system can directly regulate serum insulin levels

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888513

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888513

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3888513

Melanocortin-4 receptor agonists for the treatment of obesity

27 November 2018

1 reference

12 December 2020

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

1 reference

12 December 2020

Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates

1 reference

12 December 2020

Enzyme immunoassay for intact human insulin in serum or plasma

1 reference

12 December 2020

1 reference

12 December 2020