Integrin signalling adaptors: not only figurants in the cancer story (Q28299126)

Integrins and signal transduction

31 March 2020

2 references

31 March 2020

12 December 2020

CAS proteins in normal and pathological cell growth control

1 reference

p130Cas: a versatile scaffold in signaling networks

31 March 2020

1 reference

Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

31 March 2020

1 reference

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

31 March 2020

1 reference

A novel Cas family member, HEPL, regulates FAK and cell spreading

31 March 2020

1 reference

Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

31 March 2020

1 reference

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase

31 March 2020

1 reference

p130Cas is an essential transducer element in ErbB2 transformation

31 March 2020

1 reference

p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.

31 March 2020

1 reference

BCAR1/p130Cas expression in untreated and acquired tamoxifen-resistant human breast carcinomas.

31 March 2020

1 reference

The prognostic value of BCAR1 in patients with primary breast cancer.

31 March 2020

1 reference

Modeling malignant melanoma in mice: pathogenesis and maintenance

31 March 2020

1 reference

Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

31 March 2020

1 reference

Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent

31 March 2020

1 reference

NEDD9 promotes oncogenic signaling in mammary tumor development.

31 March 2020

1 reference

Two species of human CRK cDNA encode proteins with distinct biological activities

31 March 2020

1 reference

Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas

31 March 2020

1 reference

Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers

31 March 2020

1 reference

Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4.

31 March 2020

1 reference

CrkII transgene induces atypical mammary gland development and tumorigenesis

31 March 2020

1 reference

There's something about ILK.

31 March 2020

1 reference

Integrin-linked kinase--essential roles in physiology and cancer biology.

31 March 2020

1 reference

Integrin-linked kinase: a cancer therapeutic target unique among its ILK.

31 March 2020

1 reference

Expression of integrin-linked kinase is increased in differentiated cells

31 March 2020

1 reference

Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

31 March 2020

1 reference

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

31 March 2020

1 reference

Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development

31 March 2020

1 reference

Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer

31 March 2020

1 reference

The signaling adapter protein PINCH is up-regulated in the stroma of common cancers, notably at invasive edges

31 March 2020

1 reference

Stromal staining for PINCH is an independent prognostic indicator in colorectal cancer

31 March 2020

1 reference

p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation.

31 March 2020

1 reference

p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity

31 March 2020

1 reference

P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading

31 March 2020

1 reference

SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis

31 March 2020

1 reference

A novel murine gene, Sickle tail, linked to the Danforth's short tail locus, is required for normal development of the intervertebral disc

31 March 2020

1 reference

Association of the tag SNPs in the human SKT gene (KIAA1217) with lumbar disc herniation

31 March 2020

1 reference

Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex

31 March 2020

1 reference

Phosphoproteomic analysis of synaptosomes from human cerebral cortex

31 March 2020

1 reference

Proteomic analysis of in vivo phosphorylated synaptic proteins.

31 March 2020

1 reference

SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue

31 March 2020

1 reference

Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

31 March 2020

1 reference

Mammalian Rho GTPases: new insights into their functions from in vivo studies

31 March 2020

1 reference

Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling

31 March 2020

1 reference

Random versus directionally persistent cell migration

31 March 2020

1 reference

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK

31 March 2020

1 reference

Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII.

31 March 2020

1 reference

Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling?

31 March 2020

1 reference

The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration

31 March 2020

1 reference

Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers

31 March 2020

1 reference

CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases

31 March 2020

1 reference

Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells

31 March 2020

1 reference

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

31 March 2020

1 reference

Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing

31 March 2020

1 reference

Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas

31 March 2020

1 reference

Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge

31 March 2020

1 reference

Rac activation and inactivation control plasticity of tumor cell movement

31 March 2020

1 reference

HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells

31 March 2020

1 reference

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

31 March 2020

1 reference

31 March 2020

1 reference

Epithelial-mesenchymal transitions in development and disease

31 March 2020

1 reference

Transforming growth factor-beta 1-induced apoptosis is blocked by beta 1-integrin-mediated mitogen-activated protein kinase activation in human hepatoma cells

31 March 2020

1 reference

The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling

31 March 2020

1 reference

p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.

31 March 2020

1 reference

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility

31 March 2020

1 reference

Complex networks orchestrate epithelial-mesenchymal transitions

31 March 2020

1 reference

Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression

31 March 2020

1 reference

Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells

31 March 2020

1 reference

Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1

31 March 2020

1 reference

Basic helix-loop-helix protein E47-mediated p21Waf1/Cip1 gene expression regulates apoptosis of intestinal epithelial cells

31 March 2020

1 reference

The 31-kDa caspase-generated cleavage product of p130cas functions as a transcriptional repressor of E2A in apoptotic cells

31 March 2020

1 reference

The docking protein HEF1 is an apoptotic mediator at focal adhesion sites

31 March 2020

1 reference

A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage

31 March 2020

1 reference

PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells

31 March 2020

1 reference

Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells

31 March 2020

1 reference

Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents?

31 March 2020

1 reference

Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas.

31 March 2020

1 reference

A celecoxib derivative inhibits focal adhesion signaling and induces caspase-8-dependent apoptosis in human acute myeloid leukemia cells.

31 March 2020

1 reference

Characterization of the kinase activity essential for tyrosine phosphorylation of p130Cas in fibroblasts

31 March 2020

1 reference

CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas

31 March 2020

1 reference

v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation

31 March 2020

1 reference

Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration

31 March 2020

1 reference

Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines

31 March 2020

1 reference

MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines

31 March 2020

1 reference

ILK, PINCH and parvin: the tIPP of integrin signalling

31 March 2020

1 reference

Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.

31 March 2020

1 reference

A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction

31 March 2020

1 reference

Integrin-linked kinase is an adaptor with essential functions during mouse development

31 March 2020

1 reference

Integrin-linked kinase is a functional Mn2 -dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation

31 March 2020

1 reference

The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

31 March 2020

1 reference

Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.

31 March 2020

1 reference

The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9).

31 March 2020

1 reference

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

31 March 2020

1 reference

Oncogenic ILK, tumor suppression and all that JNK.

31 March 2020

1 reference

Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival

31 March 2020

1 reference

PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival

31 March 2020

1 reference

Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation

31 March 2020

1 reference

Evaluation of PARVG located on 22q13 as a candidate tumor suppressor gene for colorectal and breast cancer

31 March 2020

1 reference

PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells

31 March 2020

1 reference

Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures.

31 March 2020

1 reference

Proximal protein tyrosine kinases in immunoreceptor signaling

31 March 2020

1 reference

E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions

31 March 2020

1 reference

E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases.

31 March 2020

1 reference

Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion

31 March 2020

1 reference

Androgen receptor-mediated repression of novel target genes

31 March 2020

1 reference

Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity

31 March 2020

1 reference

p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells

31 March 2020

1 reference

BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells

31 March 2020

1 reference

Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells

31 March 2020

1 reference

Tamoxifen resistance in breast cancer: elucidating mechanisms

31 March 2020

1 reference

p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.

31 March 2020

1 reference

AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern

31 March 2020

1 reference

The substrate domain of BCAR1 is essential for anti-estrogen-resistant proliferation of human breast cancer cells

31 March 2020

1 reference

A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells

31 March 2020

1 reference

Cas-L was overexpressed in imatinib-resistant gastrointestinal stromal tumor cells

31 March 2020

1 reference

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

31 March 2020

1 reference

The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth.

31 March 2020

1 reference

Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK).

31 March 2020

1 reference

Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xe

31 March 2020

1 reference

The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity

31 March 2020

1 reference

Growth control by intracellular tension and extracellular stiffness

31 March 2020

1 reference

Signal co-operation between integrins and other receptor systems

31 March 2020

1 reference

An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression

31 March 2020

1 reference

beta 1 integrin function in vivo: adhesion, migration and more

31 March 2020

1 reference

New signals from the invasive front

31 March 2020

1 reference

beta1 integrin targeting to enhance radiation therapy

31 March 2020

1 reference

{beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.

31 March 2020

1 reference

Integrins: masters and slaves of endocytic transport.

31 March 2020

1 reference

Mutant p53 drives invasion by promoting integrin recycling

31 March 2020

1 reference

p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene

31 March 2020

1 reference

HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L).

31 March 2020

1 reference

ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway

31 March 2020

1 reference

Increased expression of integrin-linked kinase is associated with shorter survival in non-small cell lung cancer

31 March 2020

1 reference

Integrin-linked kinase activity is associated with interleukin-1 alpha-induced progressive behavior of pancreatic cancer and poor patient survival

31 March 2020

1 reference

Thymosin beta4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase.

31 March 2020

1 reference

Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid

31 March 2020

1 reference

Reactivity of integrin-linked kinase in human mesothelial cell proliferation.

31 March 2020

1 reference

ILK (beta1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour

31 March 2020

1 reference

PINCH expression and its significance in esophageal squamous cell carcinoma

31 March 2020

1 reference

Expression of PINCH protein in gliomas and its clinicopathological significance

31 March 2020

1 reference

Particularly interesting new cysteine-histidine rich protein expression in colorectal adenocarcinomas

31 March 2020

1 reference

Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

31 March 2020

1 reference

12 December 2020

Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells

1 reference

12 December 2020

Immunohistochemical study of the BCAR1/p130Cas protein in non-malignant and malignant human breast tissue.

1 reference

12 December 2020

CrkI adapter protein modulates cell migration and invasion in glioblastoma

1 reference

12 December 2020

Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival.

1 reference

12 December 2020

Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn

1 reference

12 December 2020

Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon

1 reference

12 December 2020

JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma

1 reference

12 December 2020

Forcing form and function: biomechanical regulation of tumor evolution

1 reference

12 December 2020

Integrin-linked kinase expression increases with prostate tumor grade

1 reference

12 December 2020

A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells

1 reference

12 December 2020

Isolation and chromosomal localization of CRKL, a human crk-like gene

1 reference

12 December 2020

Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis

1 reference

12 December 2020

Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis.

1 reference

12 December 2020

p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1

1 reference

12 December 2020

Integrin-linked kinase inhibitor KP-392 demonstrates clinical benefits in an orthotopic human non-small cell lung cancer model

1 reference

12 December 2020