HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability (Q28294885)

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Louise J Barber

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Allison J Clark

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Julie S Martin

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Jordan D Ward

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Simon J Boulton

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

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language of work or name

English

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publication date

April 2007

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published in

Nature Cell Biology

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volume

9

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issue

4

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page(s)

391-401

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cites work

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Cell-cycle checkpoints and cancer

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The DNA damage response: putting checkpoints in perspective

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo

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C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein

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Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

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Human claspin is required for replication checkpoint control

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MDC1 is required for the intra-S-phase DNA damage checkpoint

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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MDC1 is a mediator of the mammalian DNA damage checkpoint

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

21 April 2017

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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Chk1 is required to maintain claspin stability

21 April 2017

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Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

21 April 2017

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 April 2017

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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

21 April 2017

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Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation

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Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

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gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

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The Fanconi Anemia/BRCA pathway: new faces in the crowd

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Circadian clock genes as modulators of sensitivity to genotoxic stress.

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The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells

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The Neurospora checkpoint kinase 2: a regulatory link between the circadian and cell cycles

21 January 2018

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Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans

21 January 2018

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A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

21 January 2018

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Human TopBP1 ensures genome integrity during normal S phase

21 January 2018

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

21 January 2018

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

21 January 2018

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Chk1 is haploinsufficient for multiple functions critical to tumor suppression

21 January 2018

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ATR couples FANCD2 monoubiquitination to the DNA-damage response

21 January 2018

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Nbs1 is required for ATR-dependent phosphorylation events

21 January 2018

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Double-strand-break-induced homologous recombination in mammalian cells

21 January 2018

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Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks

21 January 2018

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Checking on DNA damage in S phase

21 January 2018

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Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

21 January 2018

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Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

21 January 2018

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The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability

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Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis

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Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage.

21 January 2018

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7 January 2021

Inhibition of DNA synthesis by ionizing radiation: a marker for an S-phase checkpoint

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7 January 2021

Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway

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7 January 2021

C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair

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7 January 2021