Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression (Q28294651)

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5 March 2020

title

Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression (English)

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5 March 2020

4

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5 March 2020

author name string

Ivan Nemazanyy

series ordinal

1

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5 March 2020

Catherine Espeillac

series ordinal

2

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5 March 2020

Mario Pende

series ordinal

3

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5 March 2020

language of work or name

English

0 references

publication date

1 August 2013

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Biochemical Society Transactions

5 March 2020

published in

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volume

41

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issue

4

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5 March 2020

page(s)

917-922

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

5 March 2020

cites work

1 reference

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

21 April 2017

1 reference

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

21 April 2017

1 reference

TOR signaling in growth and metabolism

21 April 2017

1 reference

Defining the role of mTOR in cancer

21 April 2017

1 reference

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 April 2017

1 reference

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

21 April 2017

1 reference

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 April 2017

1 reference

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

21 April 2017

1 reference

Identification of small molecule inhibitors of pyruvate kinase M2

21 April 2017

1 reference

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 April 2017

1 reference

Hepatocellular carcinoma pathogenesis: from genes to environment

21 April 2017

1 reference

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 April 2017

1 reference

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

21 April 2017

1 reference

Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

21 April 2017

1 reference

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten /- mice

21 April 2017

1 reference

mTOR inhibitors for hepatocellular cancer: a forward-moving target

21 January 2018

1 reference

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

21 January 2018

1 reference

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

21 January 2018

1 reference

Tenets of PTEN tumor suppression

21 January 2018

1 reference

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation

21 January 2018

1 reference

Akt1 governs breast cancer progression in vivo

21 January 2018

1 reference

The deficiency of Akt1 is sufficient to suppress tumor development in Pten /- mice

21 January 2018

1 reference

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

21 January 2018

1 reference

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

PPARγ contributes to PKM2 and HK2 expression in fatty liver

21 January 2018

1 reference

Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

21 January 2018

1 reference

The critical role of AKT2 in hepatic steatosis induced by PTEN loss

21 January 2018

1 reference

Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.

21 January 2018

1 reference

Promise of rapalogues versus mTOR kinase inhibitors in subset specific breast cancer: old targets new hope

21 January 2018

1 reference

Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma

21 January 2018

1 reference

Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

21 January 2018

1 reference

Phase 1/2 study of everolimus in advanced hepatocellular carcinoma

21 January 2018

1 reference

Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer

21 January 2018

1 reference

Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis

21 January 2018

1 reference

The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet

21 January 2018

1 reference

S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1042/BST20130034

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23863156 AND SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23863156 AND SRC:MED&resulttype=core&format=json