DNA topoisomerases and their poisoning by anticancer and antibacterial drugs (Q28284744)

New inhibitors of bacterial topoisomerase GyrA/ParC subunits.

Europe PubMed Central

title

DNA topoisomerases and their poisoning by anticancer and antibacterial drugs (English)

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1

Yves Pommier

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author name string

Elisabetta Leo

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2

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HongLiang Zhang

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3

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Christophe Marchand

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4

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language of work or name

English

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publication date

28 May 2010

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published in

Chemistry and Biology

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volume

17

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issue

5

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page(s)

421-33

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cites work

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Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells

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An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay).

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Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

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Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

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Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

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Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

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Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agents

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DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression

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Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage

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Cell cycle kinases as therapeutic targets for cancer

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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

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Human TOP3: a single-copy gene encoding DNA topoisomerase III

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Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints

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Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex

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Altered serine/arginine-rich protein phosphorylation and exonic enhancer-dependent splicing in Mammalian cells lacking topoisomerase I.

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Human mitochondrial topoisomerase I

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Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase

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DNA topoisomerase I is essential in Drosophila melanogaster

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Interaction between DNA and an Escherichia coli protein omega

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A protease pathway for the repair of topoisomerase II-DNA covalent complexes

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Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

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Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line

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Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationship

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Quinolones: action and resistance updated

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

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Vaccinia DNA topoisomerase I: evidence supporting a free rotation mechanism for DNA supercoil relaxation

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Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis

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Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin

1 reference

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Single- and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide

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Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin

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Vaccinia virus DNA topoisomerase: a model eukaryotic type IB enzyme

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Supercoiling of the DNA template during transcription

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Origin and evolution of DNA topoisomerases

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The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography

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A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

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Chk2 molecular interaction map and rationale for Chk2 inhibitors

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A journey in the world of DNA rings and beyond

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

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Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

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Next generation topoisomerase I inhibitors: Rationale and biomarker strategies

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Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases

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Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture

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