Disruption of GW bodies impairs mammalian RNA interference (Q28281500)

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object named as

Marvin J Fritzler

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author name string

Andrew Jakymiw

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Shangli Lian

2

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Theophany Eystathioy

3

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Songqing Li

4

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John C Hamel

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Edward K L Chan

A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles

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language of work or name

English

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publication date

December 2005

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published in

Nature Cell Biology

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volume

7

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issue

12

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page(s)

1267-74

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cites work

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The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies

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MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

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Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

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Mechanisms of gene silencing by double-stranded RNA

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Argonaute2 is the catalytic engine of mammalian RNAi

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

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Cytoplasmic foci are sites of mRNA decay in human cells

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Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

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A microRNA in a multiple-turnover RNAi enzyme complex

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Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

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GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation

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Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182

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ATP requirements and small interfering RNA structure in the RNA interference pathway

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Revealing the world of RNA interference

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Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

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Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

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RNAi in human cells: basic structural and functional features of small interfering RNA.

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A link between mRNA turnover and RNA interference in Arabidopsis.

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AtXRN4 degrades mRNA in Arabidopsis and its substrates include selected miRNA targets

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The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans

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The nuclear pore complex protein Tpr is a common autoantigen in sera that demonstrate nuclear envelope staining by indirect immunofluorescence

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Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera.

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GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization

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Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis

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A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

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