The bacterial ribosome as a target for antibiotics (Q28279726)

Nature Reviews Microbiology

Europe PubMed Central

title

The bacterial ribosome as a target for antibiotics (English)

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2

Stephen Douthwaite

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author name string

Jacob Poehlsgaard

series ordinal

1

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language of work or name

English

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publication date

November 2005

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published in

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volume

3

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issue

11

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page(s)

870-81

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cites work

Visualizing tmRNA entry into a stalled ribosome

1 reference

Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy

21 April 2017

1 reference

The structural basis of ribosome activity in peptide bond synthesis

21 April 2017

1 reference

Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression

21 April 2017

1 reference

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451

21 April 2017

1 reference

Structure of the 30S ribosomal subunit

21 April 2017

1 reference

Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution

21 April 2017

1 reference

Crystal structure of the ribosome at 5.5 A resolution

21 April 2017

1 reference

The path of messenger RNA through the ribosome

21 April 2017

1 reference

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

21 April 2017

1 reference

High resolution structure of the large ribosomal subunit from a mesophilic eubacterium

21 April 2017

1 reference

X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli

21 April 2017

1 reference

Structural insight into the role of the ribosomal tunnel in cellular regulation

21 April 2017

1 reference

Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic

21 April 2017

1 reference

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

21 April 2017

1 reference

Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide

21 April 2017

1 reference

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

21 April 2017

1 reference

The structures of four macrolide antibiotics bound to the large ribosomal subunit

21 April 2017

1 reference

Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit

21 April 2017

1 reference

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

21 April 2017

1 reference

Recognition of cognate transfer RNA by the 30S ribosomal subunit

21 April 2017

1 reference

Ribosomal Crystallography: Initiation, Peptide Bond Formation, and Amino Acid Polymerization are Hampered by Antibiotics

21 April 2017

1 reference

Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

21 April 2017

1 reference

L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin

21 April 2017

1 reference

The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit

21 April 2017

1 reference

Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site

21 April 2017

1 reference

Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

21 April 2017

1 reference

Interaction of antibiotics with functional sites in 16S ribosomal RNA

21 April 2017

1 reference

Architecture of the Escherichia coli ribosome as determined by immune electron microscopy

21 April 2017

1 reference

Structural studies of the translational apparatus

21 January 2018

1 reference

The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer

21 January 2018

1 reference

Ribosome-catalyzed peptide-bond formation with an A-site substrate covalently linked to 23S ribosomal RNA.

21 January 2018

1 reference

A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line

21 January 2018

1 reference

The Structural Basis of Large Ribosomal Subunit Function

21 January 2018

1 reference

The ribosome as an entropy trap

21 January 2018

1 reference

The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release

21 January 2018

1 reference

Characterization and preliminary attempts for derivatization of crystals of large ribosomal subunits from Haloarcula marismortui diffracting to 3 A resolution

21 January 2018

1 reference

Thermus thermophilus ribosomes for crystallographic studies

21 January 2018

1 reference

The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit

21 January 2018

1 reference

RNA chaperone activity of large ribosomal subunit proteins from Escherichia coli

21 January 2018

1 reference

The driving force for molecular evolution of translation

21 January 2018

1 reference

mRNA helicase activity of the ribosome

21 January 2018

1 reference

The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.

21 January 2018

1 reference

Regulatory nascent peptides in the ribosomal tunnel

21 January 2018

1 reference

Control of SecA and SecM translation by protein secretion

21 January 2018

1 reference

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

21 January 2018

1 reference

Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.

21 January 2018

1 reference

Structural origins of gentamicin antibiotic action

21 January 2018

1 reference

Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site

21 January 2018

1 reference

Drugs targeting the ribosome

21 January 2018

1 reference

Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.

21 January 2018

1 reference

The translation initiation functions of IF2: targets for thiostrepton inhibition.

21 January 2018

1 reference

Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain

21 January 2018

1 reference

Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-negative bacteria

21 January 2018

1 reference

A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.

21 January 2018

1 reference

Interaction of avilamycin with ribosomes and resistance caused by mutations in 23S rRNA.

21 January 2018

1 reference

The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose

21 January 2018

1 reference

Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.

21 January 2018

1 reference

Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin

21 January 2018

1 reference

Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center

21 January 2018

1 reference

The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo

21 January 2018

1 reference

Recognition of the codon-anticodon helix by ribosomal RNA.

21 January 2018

1 reference

Insights into the decoding mechanism from recent ribosome structures

21 January 2018

1 reference

Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome

21 January 2018

1 reference

An active role for tRNA in decoding beyond codon:anticodon pairing

21 January 2018

1 reference

Mutagenesis of 16S rRNA C1409-G1491 base-pair differentiates between 6'OH and 6'NH3 aminoglycosides

21 January 2018

1 reference

A mutation in the decoding center of Thermus thermophilus 16S rRNA suggests a novel mechanism of streptomycin resistance

21 January 2018

1 reference

Methylation of 16S ribosomal RNA and resistance to the aminoglycoside antibiotics gentamicin and kanamycin determined by DNA from the gentamicin-producer, Micromonospora purpurea.

21 January 2018

1 reference

Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides

21 January 2018

1 reference

Instruction of translating ribosome by nascent peptide

21 January 2018

1 reference

Erythromycin resistance by ribosome modification

21 January 2018

1 reference

The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome

21 January 2018

1 reference

Insights into erythromycin action from studies of its activity as inducer of resistance

21 January 2018

1 reference

Short peptides conferring resistance to macrolide antibiotics

21 January 2018

1 reference

Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin

21 January 2018

1 reference

Bacterial ribosomal subunit assembly is an antibiotic target

21 January 2018

1 reference

Translation and protein synthesis: macrolides

21 January 2018

1 reference

Ketolides-telithromycin, an example of a new class of antibacterial agents

21 January 2018

1 reference

Activities of telithromycin against 13,874 Streptococcus pneumoniae isolates collected between 1999 and 2003.

21 January 2018

1 reference

Structural basis for the antibiotic activity of ketolides and azalides

21 January 2018

1 reference

23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.

21 January 2018

1 reference

Cloning of tlrD, a fourth resistance gene, from the tylosin producer, Streptomyces fradiae

21 January 2018

1 reference

Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae

21 January 2018

1 reference

Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy

21 January 2018

1 reference

Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.

21 January 2018

1 reference

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

21 January 2018

1 reference

The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA.

21 January 2018

1 reference

Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA

21 January 2018

1 reference

Binding site of the bridged macrolides in the Escherichia coli ribosome

21 January 2018

1 reference

Macrolide resistance conferred by base substitutions in 23S rRNA.

21 January 2018

1 reference

The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059.

21 January 2018

1 reference

Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins

21 January 2018

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Properties of ribosomes from erythromycin resistant mutants of Escherichia coli

21 January 2018

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Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli

21 January 2018

1 reference

Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage

21 January 2018

1 reference

In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations

21 January 2018

1 reference

Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA.

21 January 2018

1 reference

Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics

21 January 2018

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Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

21 January 2018

1 reference

The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748.

21 January 2018

1 reference

In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides

21 January 2018

1 reference

The macrolide binding site on the bacterial ribosome

21 January 2018

1 reference

Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex

21 January 2018

1 reference

Ribosome structure determined by electron microscopy of Escherichia coli small subunits, large subunits and monomeric ribosomes

21 January 2018

1 reference

Peptide bond formation by in vitro selected ribozymes

31 March 2020

1 reference

Parameters for crystal growth of ribosomal subunits

31 March 2020

1 reference

Preliminary X-ray investigation of 70 S ribosome crystals from Thermus thermophilus

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRMICRO1265

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1030281680

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Fatcat ID

release_6i7kjbnbrvexzlvtrzwtookeky

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Fatcat

https://api.fatcat.wiki/v0/release/6i7kjbnbrvexzlvtrzwtookeky

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

16261170

1 reference

Consolidated OpenCitations Corpus – April 2017