A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis (Q28267330)

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Nadine S Jahchan

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Eunmee Hong

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Qiang Li

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Mark A Bayfield

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Richard J Maraia

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Kunxin Luo

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Qiang Zhou

Cre-lox-regulated conditional RNA interference from transgenes

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language of work or name

English

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publication date

14 March 2008

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published in

Molecular Cell

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volume

29

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issue

5

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page(s)

588-99

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cites work

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12 December 2020

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

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12 December 2020

Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.

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12 December 2020

Increased HEXIM1 expression during erythroleukemia and neuroblastoma cell differentiation

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12 December 2020

Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function

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12 December 2020

Role of PTHrp and PTHrp-engaged pathways in MCF-7 cells migration/invasion

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12 December 2020

Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186

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12 December 2020

Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.

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12 December 2020

siRNA depletion of 7SK snRNA induces apoptosis but does not affect expression of the HIV-1 LTR or P-TEFb-dependent cellular genes

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12 December 2020

Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis

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12 December 2020

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12 December 2020

RNA polymerase III transcription--a battleground for tumour suppressors and oncogenes

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12 December 2020

Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation

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12 December 2020

Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen

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12 December 2020

MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

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12 December 2020

Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366

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12 December 2020

Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer

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12 December 2020

Controlling the elongation phase of transcription with P-TEFb

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12 December 2020

CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo

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12 December 2020

U snRNP assembly in yeast involves the La protein

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12 December 2020

Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation

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12 December 2020

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

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12 December 2020

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

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12 December 2020

Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers.

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12 December 2020

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

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12 December 2020

Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro

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12 December 2020

The La protein-RNA complex surfaces.

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12 December 2020

The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation

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12 December 2020

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

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12 December 2020

Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase

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12 December 2020

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme

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12 December 2020

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

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12 December 2020

Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription

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12 December 2020

Regulation of larval hematopoiesis in Drosophila melanogaster: a role for the multi sex combs gene.

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12 December 2020

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

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12 December 2020