Regulation of tumour necrosis factor signalling: live or let die (Q28262381)

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15 February 2020

review article

1 reference

title

Regulation of tumour necrosis factor signalling: live or let die (English)

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15 February 2020

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15 February 2020

author name string

Heiko Blaser

series ordinal

2

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15 February 2020

Tak W Mak

series ordinal

3

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15 February 2020

language of work or name

English

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publication date

1 June 2015

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Nature Reviews Immunology

15 February 2020

published in

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15 February 2020

volume

15

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15 February 2020

issue

6

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15 February 2020

page(s)

362-374

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Signalling pathways of the TNF superfamily: a double-edged sword

15 February 2020

cites work

1 reference

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

21 January 2018

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A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF

21 January 2018

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

21 January 2018

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Structure of tumour necrosis factor

21 January 2018

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Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

21 January 2018

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iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

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TNF receptor 2 pathway: drug target for autoimmune diseases

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Death receptor signaling

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A novel domain within the 55 kd TNF receptor signals cell death

21 January 2018

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

21 January 2018

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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

21 January 2018

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Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

21 January 2018

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Regulated commitment of TNF receptor signaling: a molecular switch for death or activation.

21 January 2018

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Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

21 January 2018

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TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

21 January 2018

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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

21 January 2018

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A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

21 January 2018

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Tumor necrosis factor receptor 2 (TNFR2) signaling is negatively regulated by a novel, carboxyl-terminal TNFR-associated factor 2 (TRAF2)-binding site

21 January 2018

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Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

21 January 2018

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Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

21 January 2018

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The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

21 January 2018

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The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

21 January 2018

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Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

21 January 2018

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21 January 2018

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21 January 2018

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Origin and function of ubiquitin-like proteins

21 January 2018

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

1 reference

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

21 January 2018

1 reference

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

21 January 2018

1 reference

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

21 January 2018

1 reference

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

21 January 2018

1 reference

A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

21 January 2018

1 reference

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

21 January 2018

1 reference

Linear ubiquitination prevents inflammation and regulates immune signalling

21 January 2018

1 reference

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

21 January 2018

1 reference

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

21 January 2018

1 reference

A ubiquitin ligase complex assembles linear polyubiquitin chains

21 January 2018

1 reference

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

21 January 2018

1 reference

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

21 January 2018

1 reference

The IKK complex, a central regulator of NF-kappaB activation

21 January 2018

1 reference

Circuitry of nuclear factor kappaB signaling

21 January 2018

1 reference

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

1 reference

Structural Basis for Recognition of Diubiquitins by NEMO

21 January 2018

1 reference

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

1 reference

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

21 January 2018

1 reference

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

21 January 2018

1 reference

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

21 January 2018

1 reference

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

1 reference

Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing

21 January 2018

1 reference

Mitochondrial cell death effectors.

21 January 2018

1 reference

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

1 reference

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

1 reference

NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling

21 January 2018

1 reference

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation

21 January 2018

1 reference

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

21 January 2018

1 reference

TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

1 reference

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

21 January 2018

1 reference

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

1 reference

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

21 January 2018

1 reference

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

Structural basis of IAP recognition by Smac/DIABLO

21 January 2018

1 reference

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

1 reference

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

1 reference

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells

21 January 2018

1 reference

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

21 January 2018

1 reference

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

21 January 2018

1 reference

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

1 reference

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

c-FLIPR, a new regulator of death receptor-induced apoptosis.

21 January 2018

1 reference

NF-kappaB signals induce the expression of c-FLIP.

21 January 2018

1 reference

NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

21 January 2018

1 reference

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

21 January 2018

1 reference

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

1 reference

Survival function of the FADD-CASPASE-8-cFLIP(L) complex

21 January 2018

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Inhibition of death receptor signals by cellular FLIP

21 January 2018

1 reference

Casper is a FADD- and caspase-related inducer of apoptosis

21 January 2018

1 reference

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

21 January 2018

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

21 January 2018

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

21 January 2018

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Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

21 January 2018

1 reference

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

21 January 2018

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

21 January 2018

1 reference

Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1

21 January 2018

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Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex

21 January 2018

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Molecular mechanisms of necroptosis: an ordered cellular explosion

21 January 2018

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The RIP kinases: crucial integrators of cellular stress

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Receptor-interacting protein (RIP) kinase family.

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Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.

21 January 2018

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The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

21 January 2018

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.

21 January 2018

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

21 January 2018

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Functional complementation between FADD and RIP1 in embryos and lymphocytes

21 January 2018

1 reference

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

21 January 2018

1 reference

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

21 January 2018

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Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.

21 January 2018

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TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

21 January 2018

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Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

21 January 2018

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HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death

21 January 2018

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Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

21 January 2018

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

21 January 2018

1 reference

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

21 January 2018

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Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

21 January 2018

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Structural insights into RIP3-mediated necroptotic signaling

21 January 2018

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Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

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Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

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TNF-mediated inflammatory disease.

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TNF superfamily in inflammatory disease: translating basic insights

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Clinical targeting of the TNF and TNFR superfamilies

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The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation

31 March 2020

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Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

12 December 2020

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

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12 December 2020

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RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis

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12 December 2020

Identifiers

DOI

10.1038/NRI3834

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26008591 AND SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017