Non-homologous end-joining, a sticky affair (Q28260337)

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

Europe PubMed Central

title

Non-homologous end-joining, a sticky affair (English)

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author name string

D C van Gent

series ordinal

1

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M van der Burg

series ordinal

2

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language of work or name

English

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publication date

10 December 2007

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published in

Oncogene

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volume

26

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issue

56

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page(s)

7731-40

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cites work

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Ku recruits the XRCC4-ligase IV complex to DNA ends

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Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions

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Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.

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Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

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DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

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7 January 2021

Omenn syndrome due to ARTEMIS mutations

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H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

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7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

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7 January 2021

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

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7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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7 January 2021

Mechanisms of DNA double strand break repair and chromosome aberration formation

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Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus

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7 January 2021

Double-strand break repair in Ku86- and XRCC4-deficient cells

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7 January 2021

The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts

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7 January 2021

Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families

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7 January 2021

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

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7 January 2021

ATM activation and DNA damage response

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7 January 2021

Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage.

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Responding to DNA double strand breaks in the nervous system

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The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

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7 January 2021

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

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7 January 2021

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

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7 January 2021

ATM and ataxia telangiectasia

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trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining

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7 January 2021

Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive

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7 January 2021

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

1 reference

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7 January 2021

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

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7 January 2021

Track structure in radiation biology: theory and applications.

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7 January 2021

Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow.

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7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

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7 January 2021

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

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7 January 2021

Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

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7 January 2021

Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

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https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

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https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Rad52 and Ku bind to different DNA structures produced early in double-strand break repair

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https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

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7 January 2021

https://api.crossref.org/works/10.1038/SJ.ONC.1210871

1 reference

7 January 2021

RAG mutations in human B cell-negative SCID.

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7 January 2021

The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit

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https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

The role of DNA damage response proteins at telomeres--an "integrative" model

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7 January 2021

The DNA-dependent protein kinase

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7 January 2021

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

A new type of radiosensitive T-B-NK severe combined immunodeficiency caused by a LIG4 mutation.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Defective Artemis nuclease is characterized by coding joints with microhomology in long palindromic-nucleotide stretches

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https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4.

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7 January 2021

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

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https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression

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7 January 2021

The mechanism of non-homologous end-joining: a synopsis of synapsis

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7 January 2021

The role of DNA dependent protein kinase in synapsis of DNA ends.

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7 January 2021

Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

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https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

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7 January 2021

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells

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https://api.crossref.org/works/10.1038/SJ.ONC.1210871

7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

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7 January 2021