Potential pharmacological interventions in polycystic kidney disease (Q28258516)

polycystic kidney disease

Europe PubMed Central

title

Potential pharmacological interventions in polycystic kidney disease (English)

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inferred from title

author

Robert William Schrier

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object named as

Robert W Schrier

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author name string

Amirali Masoumi

1

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Berenice Reed-Gitomer

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Catherine Kelleher

Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease

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language of work or name

English

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publication date

2007

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published in

Drugs

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volume

67

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issue

17

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page(s)

2495-510

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cites work

1 reference

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Effect of inhibition of converting enzyme on renal hemodynamics and sodium management in polycystic kidney disease

21 January 2018

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Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1alpha induced for impaired myocardial energy metabolism

21 January 2018

1 reference

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Effect of flow and stretch on the [Ca2 ]i response of principal and intercalated cells in cortical collecting duct

21 January 2018

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Capacitative Ca2 entry exclusively inhibits cAMP synthesis in C6-2B glioma cells. Evidence that physiologically evoked Ca2 entry regulates Ca(2 )-inhibitable adenylyl cyclase in non-excitable cells.

21 January 2018

1 reference

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Ligand-regulated secretion of recombinant annexin V from cultured thyroid epithelial cells

21 January 2018

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Integration of growth factor, extracellular matrix, and retinoid signals during bronchial epithelial cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165/00003495-200767170-00004

Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2

21 January 2018

1 reference

https://api.crossref.org/works/10.2165/00003495-200767170-00004

Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2165/00003495-200767170-00004

Increased water intake decreases progression of polycystic kidney disease in the PCK rat

21 January 2018

1 reference

12 December 2020

Caspases, Bcl-2 proteins and apoptosis in autosomal-dominant polycystic kidney disease

1 reference

12 December 2020

Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors

1 reference

12 December 2020

The target of rapamycin (TOR) proteins

1 reference

12 December 2020

PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis

1 reference

12 December 2020

Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation

1 reference

12 December 2020

Positional cloning of jcpk/bpk locus of the mouse

1 reference

12 December 2020

Left ventricular hypertrophy in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Death by Dozens of Cuts

1 reference

12 December 2020

14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity

1 reference

12 December 2020

Epidermal growth factor (EGF) expression in the congenital polycystic mouse kidney.

1 reference

12 December 2020

Mechanisms of regulating the Raf kinase family

1 reference

12 December 2020

Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2 ) homeostasis in polycystic kidney disease

1 reference

12 December 2020

Endothelin-1 inhibits AVP-stimulated osmotic water permeability in rat inner medullary collecting duct.

1 reference

12 December 2020

Functional properties of Ca2 -inhibitable type 5 and type 6 adenylyl cyclases and role of Ca2 increase in the inhibition of intracellular cAMP content

1 reference

12 December 2020

Segment-specific c-ErbB2 expression in human autosomal recessive polycystic kidney disease

1 reference

12 December 2020

Chloride and fluid secretion by cultured human polycystic kidney cells

1 reference

12 December 2020

Epidermal growth factor and endothelin in cyst fluid from autosomal dominant polycystic kidney disease cases: possible evidence of heterogeneity in cystogenesis

1 reference

12 December 2020

Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD

1 reference

12 December 2020

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

1 reference

12 December 2020

An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.

1 reference

12 December 2020

Aquaretic effect of a potent, orally active, nonpeptide V2 antagonist in men

1 reference

12 December 2020

Polycystins, calcium signaling, and human diseases.

1 reference

12 December 2020

Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells

1 reference

12 December 2020

Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells

1 reference

12 December 2020

The clinical utility of renal concentrating capacity in polycystic kidney disease.

1 reference

12 December 2020

Ion transport and cystogenesis: the paradigm of autosomal dominant polycystic kidney disease

1 reference

12 December 2020

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

12 December 2020

Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD).

1 reference

12 December 2020

Genetics and pathogenesis of polycystic kidney disease.

1 reference

12 December 2020

Indications for a 'brain-hair follicle axis (BHA)': inhibition of keratinocyte proliferation and up-regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P.

1 reference

12 December 2020

Development-dependent disappearance of caspase-3 in skeletal muscle is post-transcriptionally regulated

1 reference

12 December 2020

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

1 reference

12 December 2020

Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited

1 reference

12 December 2020

SNAREs and epithelial cells

1 reference

12 December 2020

Cyclic-3',5'-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney

1 reference

12 December 2020

Expression of transforming growth factor alpha and epidermal growth factor receptor in adult polycystic kidney disease

1 reference

12 December 2020

ETA receptor blockade induces tubular cell proliferation and cyst growth in rats with polycystic kidney disease

1 reference

12 December 2020

cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells.

1 reference

12 December 2020

Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications

1 reference

12 December 2020

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

1 reference

12 December 2020

Autosomal Recessive Polycystic Kidney Disease: The Clinical Experience in North America

1 reference

12 December 2020

Hereditary error in epidermal growth factor prohormone metabolism in a rat model of autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Growth factor gene expression in kidney of murine polycystic kidney disease

1 reference

12 December 2020

Bending the MDCK cell primary cilium increases intracellular calcium

1 reference

12 December 2020

PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles

1 reference

12 December 2020

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

1 reference

12 December 2020

Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease

1 reference

12 December 2020

Hypertension in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: recent advances

1 reference

12 December 2020

Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney disease

1 reference

12 December 2020

[The effect of hypervolemia on electrolyte level and and level of volume regulating hormones in patients with autosomal dominant polycystic kidney disease]

1 reference

12 December 2020

Epithelial transport in polycystic kidney disease

1 reference

12 December 2020

Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders

1 reference

12 December 2020

Anticancer drug targets: growth factors and growth factor signaling

1 reference

12 December 2020

The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Somatostatin limits rise in glomerular filtration rate after a protein meal

1 reference

12 December 2020

Effects of angiotensin converting enzyme inhibition in adult polycystic kidney disease

1 reference

12 December 2020

Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease

1 reference

12 December 2020

Molecular pathogenesis of ADPKD: the polycystin complex gets complex

1 reference

12 December 2020

cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI.

1 reference

12 December 2020

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

1 reference

12 December 2020

Synthesis of renin by tubulocystic epithelium in autosomal-dominant polycystic kidney disease

1 reference

12 December 2020

Modulation of cell death by Bcl-x L through caspase interaction

1 reference

12 December 2020

Pathogenesis of hypertension in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

1 reference

12 December 2020

Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk mice

1 reference

12 December 2020

The anatomy of the renin-secreting cell in adult polycystic kidney disease

1 reference

12 December 2020

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

1 reference

12 December 2020

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

1 reference

12 December 2020

AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors

1 reference

12 December 2020

Tuberous sclerosis complex: from Drosophila to human disease.

1 reference

12 December 2020

The roles of caspase-3 and bcl-2 in chemically-induced apoptosis but not necrosis of renal epithelial cells

1 reference

12 December 2020

Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

1 reference

12 December 2020

Functional activity of epidermal growth factor receptors in autosomal recessive polycystic kidney disease

1 reference

12 December 2020

Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells

1 reference

12 December 2020

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

1 reference

12 December 2020

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

1 reference

12 December 2020

[Ca2 ]i reduction increases cellular proliferation and apoptosis in vascular smooth muscle cells: relevance to the ADPKD phenotype

1 reference

12 December 2020

Deficiency of polycystin-2 reduces Ca2 channel activity and cell proliferation in ADPKD lymphoblastoid cells

1 reference

12 December 2020

Human disease: calcium signaling in polycystic kidney disease

1 reference

12 December 2020

Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice

1 reference

12 December 2020

Increasing complexity of Ras signaling.

1 reference

12 December 2020

The differential distribution of acetylated and detyrosinated alpha-tubulin in the microtubular cytoskeleton and primary cilia of hyaline cartilage chondrocytes.

1 reference

12 December 2020

Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat.

1 reference

12 December 2020

Polycystic kidney disease

1 reference

12 December 2020

The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease

1 reference

12 December 2020

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

12 December 2020

Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

1 reference

12 December 2020

The role of parental hypertension in the frequency and age of diagnosis of hypertension in offspring with autosomal-dominant polycystic kidney disease

1 reference

12 December 2020

Effect of lovastatin on the development of polycystic kidney disease in the han:SPRD rat

1 reference

12 December 2020

VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells

1 reference

12 December 2020

TSC2: filling the GAP in the mTOR signaling pathway

1 reference

12 December 2020

Arterial and glomerular lesions associated with severe hypertension. Light and electron microscopic studies

1 reference

12 December 2020

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

1 reference

12 December 2020

Defective epidermal growth factor gene expression in mice with polycystic kidney disease

1 reference

12 December 2020

Hypertension of polycystic kidney disease: mechanisms and hemodynamic alterations

1 reference

12 December 2020

Overt proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Tubular Function in Adult Polycystic Kidney Disease

1 reference

12 December 2020

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine

1 reference

12 December 2020

Chloride and fluid secretion in polycystic kidney disease

1 reference

12 December 2020

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

12 December 2020

Effect of antihypertensive therapy on renal function and urinary albumin excretion in hypertensive patients with autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells.

1 reference

12 December 2020

A transcriptional network in polycystic kidney disease

1 reference

12 December 2020

The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Renal response to intravenous somatostatin in insulin-dependent diabetic patients and normal subjects

1 reference

12 December 2020

1 reference

12 December 2020

Immunohistochemical study on hypoxia in spontaneous polycystic liver and kidney disease in rats

1 reference

12 December 2020

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

1 reference

12 December 2020

Effect of somatostatin on renal function

1 reference

12 December 2020

Epidermal growth factor receptor expression is abnormal in murine polycystic kidney

1 reference

12 December 2020

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

1 reference

12 December 2020

Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene

1 reference

12 December 2020

Dysregulation of the TSC-mTOR pathway in human disease

1 reference

12 December 2020

Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity

1 reference

12 December 2020

Apoptotic pathways: paper wraps stone blunts scissors

1 reference

12 December 2020

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1 reference

12 December 2020

Glycosylation Is Important for Cell Surface Expression of the Water Channel Aquaporin-2 but Is Not Essential for Tetramerization in the Endoplasmic Reticulum

1 reference

12 December 2020

Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure

1 reference

12 December 2020

Neural control of renal function

1 reference

12 December 2020

Renal endothelin system in polycystic kidney disease.

1 reference

12 December 2020

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

1 reference

12 December 2020

Renal concentrating capacity is linked to blood pressure in children with autosomal dominant polycystic kidney disease.

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

12 December 2020

The pathogenesis of hypertension in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Polycystin-2 accelerates Ca2 release from intracellular stores in Caenorhabditis elegans

1 reference

12 December 2020

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

12 December 2020

Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD).

1 reference

12 December 2020

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

1 reference

12 December 2020

In vitro formation and expansion of cysts derived from human renal cortex epithelial cells

1 reference

12 December 2020

Alterations in renal tubular sodium and water transport in polycystic kidney disease

1 reference

12 December 2020

Farnesyltransferase inhibitors: targeting the molecular basis of cancer

1 reference

12 December 2020

Plasma concentration of endothelin and arterial pressure in patients with ADPKD

1 reference

12 December 2020

Adult polycystic kidney disease: Studies of the defect in urine concentration

1 reference

12 December 2020

Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine

1 reference

12 December 2020

TOR, a central controller of cell growth

1 reference

12 December 2020

Specific association of the gene product of PKD2 with the TRPC1 channel

1 reference

12 December 2020

Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease

1 reference

12 December 2020

Sympathetic activity and blood pressure pattern in autosomal dominant polycystic kidney disease hypertensives

1 reference

12 December 2020

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

1 reference

12 December 2020

The Raf/MEK/ERK pathway: new concepts of activation.

1 reference

12 December 2020

Quantification and longitudinal trends of kidney, renal cyst, and renal parenchyma volumes in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

The importance of selective renal angiography in the diagnosis of polycystic disease

1 reference

12 December 2020

Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide

1 reference

12 December 2020

Causes of death in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

1 reference

12 December 2020

Dominant and recessive polycystic kidney disease in children: evaluation of clinical features and laboratory data

1 reference

12 December 2020

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2 -permeable nonselective cation channel

1 reference

12 December 2020

Human kidney as target for somatostatin: high affinity receptors in tubules and vasa recta

1 reference

12 December 2020

Two populations of node monocilia initiate left-right asymmetry in the mouse

1 reference

12 December 2020

Cardiac and renal effects of standard versus rigorous blood pressure control in autosomal-dominant polycystic kidney disease: results of a seven-year prospective randomized study

1 reference

12 December 2020

Polycystin-2 is an intracellular calcium release channel

1 reference

12 December 2020

Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist

1 reference

12 December 2020

Influence of endothelin-1 gene polymorphisms on the progression of autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys

1 reference

12 December 2020

EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats

1 reference

12 December 2020

Epidermal growth factor precursor is present in a variety of human renal cyst fluids

1 reference

12 December 2020

Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats

1 reference

12 December 2020

Diuretics versus angiotensin-converting enzyme inhibitors in autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Somatostatin analogue, octreotide, reduces increased glomerular filtration rate and kidney size in insulin-dependent diabetes

1 reference

12 December 2020

Reversal of left ventricular hypertrophy with angiotensin converting enzyme inhibition in hypertensive patients with autosomal dominant polycystic kidney disease

1 reference

12 December 2020

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

1 reference

12 December 2020

Expansion of extracellular volume in early polycystic kidney disease

1 reference

12 December 2020

Cyclic AMP differentially regulates cell proliferation of normal human keratinocytes through ERK activation depending on the expression pattern of B-Raf

1 reference

12 December 2020

Targeting mTOR signaling for cancer therapy

1 reference

12 December 2020

Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors

1 reference

12 December 2020

Apoptosis and loss of renal tissue in polycystic kidney diseases

1 reference

12 December 2020

Deregulation of cell survival in cystic and dysplastic renal development.

1 reference

12 December 2020