Potential role for therapies targeting DKK1, LRP5, and serotonin in the treatment of osteoporosis (Q28256427)

Wnt signaling in osteoblasts and bone diseases

volume

10

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issue

1

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page(s)

93-100

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cites work

1 reference

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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

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Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis

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Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation

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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

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Eight genes are highly associated with BMD variation in postmenopausal Caucasian women

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The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

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Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma.

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Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

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Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.

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Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

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Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo

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A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody

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Update in new anabolic therapies for osteoporosis

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High bone density due to a mutation in LDL-receptor-related protein 5

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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High bone mass in mice expressing a mutant LRP5 gene

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

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Lrp5 functions in bone to regulate bone mass

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

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Essential role of beta-catenin in postnatal bone acquisition

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Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis

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Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd

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Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

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Synthesis of serotonin by a second tryptophan hydroxylase isoform

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The two faces of serotonin in bone biology

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Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin

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Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5

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Relation of serum serotonin levels to bone density and structural parameters in women

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Regulation of bone mass by serotonin: molecular biology and therapeutic implications

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A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure

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Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

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The Waning of Teriparatide Effect on Bone Formation Markers in Postmenopausal Osteoporosis Is Associated with Increasing Serum Levels of DKK1

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Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

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12 December 2020

Caught up in a Wnt storm: Wnt signaling in cancer

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12 December 2020

Bone microstructural changes revealed by high-resolution peripheral quantitative computed tomography imaging and elevated DKK1 and MIP-1α levels in patients with MGUS.

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12 December 2020

Clinical and molecular findings in osteoporosis-pseudoglioma syndrome

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12 December 2020

Efficacy of serotonin inhibition in mouse models of bone loss

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12 December 2020

Osteoporosis: now and the future

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12 December 2020

LRP5, serotonin, and bone: Complexity, contradictions, and conundrums

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12 December 2020

Wnt signaling as a therapeutic target for bone diseases

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12 December 2020

The role of Dkk1 in bone mass regulation: Correlating serum Dkk1 expression with bone mineral density

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12 December 2020

Dickkopf-1 is a master regulator of joint remodeling

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12 December 2020