Galanin receptor antagonists : a potential novel pharmacological treatment for mood disorders (Q28253725)

A Molecular and Cellular Theory of Depression

Europe PubMed Central

title

Galanin receptor antagonists : a potential novel pharmacological treatment for mood disorders (English)

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Tomas Hökfelt

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Sven Ove Ögren

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1

object named as

Sven Ove Ogren

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author name string

Eugenia Kuteeva

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2

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Jan Kehr

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4

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language of work or name

English

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publication date

2006

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published in

CNS Drugs

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volume

20

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issue

8

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page(s)

633-54

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cites work

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The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test

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New perspectives on the molecular pharmacology of affective disorders

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Testing the hypothesis that locus coeruleus hyperactivity produces depression-related changes via galanin

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Intraventricular galanin modulates a 5-HT1A receptor-mediated behavioural response in the rat.

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Anxiogenic-like action of galanin after intra-amygdala administration in the rat.

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Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test

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Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain

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Galanin receptors inhibit the spontaneous firing of locus coeruleus neurones and interact with μ-opioid receptors

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Modulation of acetylcholine and serotonin transmission by galanin. Relationship to spatial and aversive learning.

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Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors

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Galanin and 5-HT1A receptor interactions as an integrative mechanism in 5-HT neurotransmission in the brain

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Galanin/GMAP- and NPY-like immunoreactivities in locus coeruleus and noradrenergic nerve terminals in the hippocampal formation and cortex with notes on the galanin-R1 and -R2 receptors

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Administration of 8-hydroxy-2-(Di-n-propylamino)tetralin in raphe nuclei dorsalis and medianus reduces serotonin synthesis in the rat brain: differences in potency and regional sensitivity

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Galanin in ascending systems. Focus on coexistence with 5-hydroxytryptamine and noradrenaline

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Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat

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Adaptative changes of the serotonergic system after antidepressant treatments

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Galanin in the cholinergic basal forebrain: histochemical, autoradiographic and in vivo studies

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Distinct mechanism for antidepressant activity by blockade of central substance P receptors

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Galanin attenuates basal and antidepressant drug-induced increase of extracellular serotonin and noradrenaline levels in the rat hippocampus

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Galanin selectively modulates 5-hydroxytryptamine 1A receptors in the rat ventral limbic cortex

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12 December 2020

Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells

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Evidence for specific N-terminal galanin fragment binding sites in the rat brain

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12 December 2020

Characterization of GalR1, GalR2, and GalR3 immunoreactivity in catecholaminergic nuclei of the mouse brain

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Cellular localization of the 5-HT1A receptor in primate brain neurons and glial cells

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On the feasibility of designing new antidepressants

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Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3

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12 December 2020

Nucleotide sequence analysis of cDNAs encoding a bovine galanin precursor protein in the adrenal medulla and chemical isolation of bovine gut galanin

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Anxiolytic-like action of centrally administered galanin

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12 December 2020

Galaninergic signalling and adenylate cyclase

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12 December 2020

A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus

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12 December 2020

Expression of preprogalanin mRNA following acute and chronic restraint stress in brains of normotensive and hypertensive rats

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12 December 2020

Learned helplessness sensitizes hippocampal norepinephrine to mild restress

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12 December 2020

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.

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12 December 2020

Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635.

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12 December 2020

Intraventricular galanin produces a time-dependent modulation of 5-HT1A receptors in the dorsal raphe of the rat.

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12 December 2020

Role of brain norepinephrine in the behavioral response to stress

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12 December 2020

Galanin receptor subtypes

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Developing novel treatments for mood disorders: accelerating discovery

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12 December 2020

Expression of galanin and nitric oxide synthase in subpopulations of serotonin neurons of the rat dorsal raphe nucleus.

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12 December 2020

Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stress

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12 December 2020

Cloning, pharmacological characterization and distribution of a novel galanin receptor

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12 December 2020

Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity

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12 December 2020

Behavioural characterisation of young adult transgenic mice overexpressing galanin under the PDGF-B promoter

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12 December 2020

Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes

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The ascent of mouse: advances in modelling human depression and anxiety

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The NPY system in stress, anxiety and depression

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The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans

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Galanin decreases the activity of locus coeruleus neurons in vitro

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12 December 2020

Galanin immunoreactivity in the primate central nervous system

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Galanin: a significant role in depression?

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Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram

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Neuropeptides--an overview.

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Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze

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Galanin is a potent in vivo modulator of mesencephalic serotonergic neurotransmission

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12 December 2020

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

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12 December 2020

Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide

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Genomic organization and functional characterization of the mouse GalR1 galanin receptor

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Discovery of antidepressant activity by forced swimming test may depend on pre-exposure of rats to a stressful situation

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12 December 2020

Galanin-5-hydroxytryptamine interactions: electrophysiological, immunohistochemical and in situ hybridization studies on rat dorsal raphe neurons with a note on galanin R1 and R2 receptors

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Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity

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Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system

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Depression: a new animal model sensitive to antidepressant treatments

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Activation of 5-HT(1A) autoreceptors enhances the inhibitory effect of galanin on hippocampal 5-HT release in vivo

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Neuropeptide Y and galanin in norepinephrine release in hypothalamic slices

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12 December 2020

Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.

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12 December 2020

Distribution of galaninlike immunoreactivity in the rat central nervous system

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Minireview. Galanin-acetylcholine interactions: relevance to memory and Alzheimer's disease

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12 December 2020

How fast are antidepressants?

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12 December 2020

In vivo serotonin release and learned helplessness

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12 December 2020

Immunohistochemical mapping of galanin-like neurons in the rat central nervous system

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12 December 2020

Galanin modulates 5-hydroxytryptamine functions. Focus on galanin and galanin fragment/5-hydroxytryptamine1A receptor interactions in the brain

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12 December 2020

Increased density of galanin binding sites in the dorsal raphe in a genetic rat model of depression.

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12 December 2020

Role of the locus coeruleus in emotional activation

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12 December 2020

Electrophysiological characterization of the effect of long-term duloxetine administration on the rat serotonergic and noradrenergic systems

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Anticonvulsant activity of a nonpeptide galanin receptor agonist

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EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS

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Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.

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12 December 2020

The 5-HT1A receptor: signaling, desensitization, and gene transcription

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Galanin and galanin antagonists: molecular and biochemical perspectives

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Effect of the 5-HT1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis

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Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

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Locus coeruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase or galanin and their efferent projections to the spinal cord, cerebral cortex and hypothalamus

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12 December 2020

Neurobiology of depression

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5-HT1A receptors, gene repression, and depression: guilt by association

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Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.

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12 December 2020

Regulation of noradrenaline release by presynaptic receptor systems

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Galanin and its receptors: introduction to the Third International Symposium, San Diego, California, USA, 21-22 October 2004.

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Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: distinct distribution from GALR1.

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Pharmacology of Antidepressants

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12 December 2020

Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice

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12 December 2020

Distribution and kinetics of galanin infused into the ventral hippocampus of the rat: relationship to spatial learning.

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12 December 2020

Relapse of depression after rapid depletion of tryptophan

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12 December 2020

Major depressive disorder

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Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist.

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Effects of sequential removal of rats from a group cage, and of individual housing of rats, on substance P, cholecystokinin and somatostatin levels in the periaqueductal grey and limbic regions

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Chronic social stress increases levels of preprogalanin mRNA in the rat locus coeruleus.

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12 December 2020

Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder

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12 December 2020

Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K channels

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12 December 2020

Serotonin type-1A receptor imaging in depression.

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Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist

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12 December 2020

Distribution of galaninergic immunoreactivity in the brain of the mouse

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12 December 2020

Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2).

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Cholinergic and peptidergic projections from the medial septum and the nucleus of the diagonal band of Broca to dorsal hippocampus, cingulate cortex and olfactory bulb: a combined wheatgerm agglutinin-apohorseradish peroxidase-gold immunohistochemic

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Galanin - a novel biologically active peptide from porcine intestine

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Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests

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Autoradiographic distribution of 125I-galanin binding sites in the rat central nervous system

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12 December 2020

Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress

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Multiple interaction sites of galnon trigger its biological effects

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12 December 2020

Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice

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Autoradiographic quantitation and anatomical mapping of 125I-galanin binding sites in the rat central nervous system

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The cellular neurobiology of depression

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Size and burden of mental disorders in Europe—a critical review and appraisal of 27 studies

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Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala.

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12 December 2020

Coexistence of peptides with classical neurotransmitters

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12 December 2020

Galanin and galanin receptors

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12 December 2020

Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy

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12 December 2020

Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior

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12 December 2020

Galanin--a neuroendocrine peptide

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Remission rates with 3 consecutive antidepressant trials: effectiveness for depressed outpatients.

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12 December 2020

A galanin-like peptide in the central nervous system and intestine of the rat

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12 December 2020

Neuropeptide Y (NPY) and depression: from animal studies to the human condition

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12 December 2020

Prolonged effects of intraventricular galanin on a 5-hydroxytryptamine(1A) receptor mediated function in the rat.

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12 December 2020

Gene-environment interaction and the genetics of depression

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12 December 2020