Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules (Q28247479)

title

Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules (English)

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3

Jon S. Thorson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21901218

11 December 2024

author name string

Pauline Peltier-Pain

2

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Richard W. Gantt

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21901218

11 December 2024

language of work or name

English

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publication date

October 2011

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8 September 2011

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21901218

full work available at URL

11 December 2024

http://pubs.rsc.org/en/content/articlepdf/2011/NP/C1NP00045D

1 reference

Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions

11 December 2024

published in

Natural Product Reports

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volume

28

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issue

11

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page(s)

1811-53

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cites work

1 reference

Discovery and design of carbohydrate-based therapeutics

22 April 2017

1 reference

Chemical approaches to glycobiology

21 January 2018

1 reference

Applications of synthetic carbohydrates to chemical biology

21 January 2018

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Chemical approaches to perturb, profile, and perceive glycans

21 January 2018

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Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research

21 January 2018

1 reference

Drug discovery beyond the 'rule-of-five'.

21 January 2018

1 reference

The impact of natural products upon modern drug discovery.

21 January 2018

1 reference

Natural glycoconjugates with antitumor activity

21 January 2018

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Update on carbohydrate-containing antibacterial agents

21 January 2018

1 reference

Sweet antibiotics - the role of glycosidic residues in antibiotic and antitumor activity and their randomization

21 January 2018

1 reference

Glycosyltransferases, important tools for drug design

21 January 2018

1 reference

Carbohydrate-based bioactive compounds for medicinal chemistry applications.

21 January 2018

1 reference

From carbohydrate leads to glycomimetic drugs

21 January 2018

1 reference

Natural products as sources of new drugs over the last 25 years

21 January 2018

1 reference

Natural products to drugs: natural product-derived compounds in clinical trials

21 January 2018

1 reference

The role of carbohydrates in biologically active natural products

21 January 2018

1 reference

Glycosides in medicine: "The role of glycosidic residue in biological activity".

21 January 2018

1 reference

Fluorinated anthracyclines: synthesis and biological activity

21 January 2018

1 reference

Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity

21 January 2018

1 reference

Catalytic topoisomerase II inhibitors in cancer therapy.

21 January 2018

1 reference

Doxorubicin: the good, the bad and the ugly effect

21 January 2018

1 reference

Improving the therapeutic index of anthracycline chemotherapy: focus on liposomal doxorubicin (Myocet).

21 January 2018

1 reference

Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials

21 January 2018

1 reference

Glucose transporters in the 21st Century

21 January 2018

1 reference

Synthesis of glycosyl derivatives as dopamine prodrugs: interaction with glucose carrier GLUT-1.

21 January 2018

1 reference

Studies on the uptake of glucose derivatives by red blood cells.

21 January 2018

1 reference

Dopaminergic properties and experimental anti-parkinsonian effects of IPX750 in rodent models of Parkinson disease

21 January 2018

1 reference

Glycosylated neuropeptides: a new vista for neuropsychopharmacology?

21 January 2018

1 reference

Glycosylation improves the central effects of DAMGO.

21 January 2018

1 reference

Promotion of microtubule assembly in vitro by taxol

21 January 2018

1 reference

Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents

21 January 2018

1 reference

A tale of two tumor targets: topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy

21 January 2018

1 reference

Cancer's molecular sweet tooth and the Warburg effect.

21 January 2018

1 reference

Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics

21 January 2018

1 reference

Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer.

21 January 2018

1 reference

Synthesis of 2'-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells

21 January 2018

1 reference

Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters

21 January 2018

1 reference

Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells

21 January 2018

1 reference

Involvement of CD44, a molecule with a thousand faces, in cancer dissemination.

21 January 2018

1 reference

Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate

21 January 2018

1 reference

A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells

21 January 2018

1 reference

Microtubule-binding agents: a dynamic field of cancer therapeutics

21 January 2018

1 reference

Targeting microtubules for cancer chemotherapy

21 January 2018

1 reference

Microtubules as a target for anticancer drugs

21 January 2018

1 reference

Total syntheses of colchicine in comparison: a journey through 50 years of synthetic organic chemistry.

21 January 2018

1 reference

A new perspective on the pharmacoeconomics of colchicine.

21 January 2018

1 reference

Colchicine in clinical medicine. A guide for internists

21 January 2018

1 reference

Colchicine glycorandomization influences cytotoxicity and mechanism of action

21 January 2018

1 reference

Enhancing the divergent activities of betulinic acid via neoglycosylation

21 January 2018

1 reference

Warfarin glycosylation invokes a switch from anticoagulant to anticancer activity.

21 January 2018

1 reference

Digitalis-induced signaling by Na /K -ATPase in human breast cancer cells.

21 January 2018

1 reference

The Na/K-ATPase-mediated signal transduction as a target for new drug development

21 January 2018

1 reference

Binding of Src to Na /K -ATPase forms a functional signaling complex

21 January 2018

1 reference

Identification of a pool of non-pumping Na/K-ATPase

21 January 2018

1 reference

The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades

21 January 2018

1 reference

Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

21 January 2018

1 reference

UNBS1450 from Calotropis procera as a regulator of signaling pathways involved in proliferation and cell death

21 January 2018

1 reference

A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis

21 January 2018

1 reference

Precision Polysaccharide Synthesis Catalyzed by Enzymes

21 January 2018

1 reference

Engineering of glycosidases and glycosyltransferases

21 January 2018

1 reference

Enzymatic transglycosylation for glycoconjugate synthesis

21 January 2018

1 reference

Leuconostoc mesenteroides glucansucrase synthesis of flavonoid glucosides by acceptor reactions in aqueous-organic solvents

21 January 2018

1 reference

Enzymatic synthesis and characterization of arbutin glucosides using glucansucrase from Leuconostoc mesenteroides B-1299CB.

21 January 2018

1 reference

Enzymatic synthesis of alkyl glucosides using Leuconostoc mesenteroides dextransucrase

21 January 2018

1 reference

Synthesis and characterization of hydroquinone fructoside using Leuconostoc mesenteroides levansucrase

21 January 2018

1 reference

Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of beta-glucuronides.

21 January 2018

1 reference

Directed evolution of a glycosynthase from Agrobacterium sp. increases its catalytic activity dramatically and expands its substrate repertoire.

21 January 2018

1 reference

Teaching old enzymes new tricks: engineering and evolution of glycosidases and glycosyl transferases for improved glycoside synthesis

21 January 2018

1 reference

A universal screening assay for glycosynthases: directed evolution of glycosynthase XynB2(E335G) suggests a general path to enhance activity

21 January 2018

1 reference

New approaches to enzymatic glycoside synthesis through directed evolution

21 January 2018

1 reference

Enzymatic thioxyloside synthesis: characterization of thioglycoligase variants identified from a site-saturation mutagenesis library of Bacillus circulans xylanase

21 January 2018

1 reference

Expanding the thioglycoligase strategy to the synthesis of alpha-linked thioglycosides allows structural investigation of the parent enzyme/substrate complex.

21 January 2018

1 reference

Engineering of a thioglycoligase: randomized mutagenesis of the acid-base residue leads to the identification of improved catalysts

21 January 2018

1 reference

Thermostable glycosynthases and thioglycoligases derived from Thermotoga maritima beta-glucuronidase

21 January 2018

1 reference

Thioglycoligase-based assembly of thiodisaccharides: screening as beta-galactosidase inhibitors

21 January 2018

1 reference

Synthesis of cellobiose from starch by the successive actions of two phosphorylases.

21 January 2018

1 reference

Practical preparation of D-galactosyl-beta1-->4-L-rhamnose employing the combined action of phosphorylases

21 January 2018

1 reference

Synthesis of highly ordered cellulose II in vitro using cellodextrin phosphorylase

21 January 2018

1 reference

Phosphorylase-catalyzed N-formyl-alpha-glucosaminylation of maltooligosaccharides

21 January 2018

1 reference

Efficient one-pot enzymatic synthesis of alpha-(1-->4)-glucosidic disaccharides through a coupled reaction catalysed by Lactobacillus acidophilus NCFM maltose phosphorylase

21 January 2018

1 reference

Recombinant sucrose phosphorylase from Leuconostoc mesenteroides: characterization, kinetic studies of transglucosylation, and application of immobilised enzyme for production of alpha-D-glucose 1-phosphate

21 January 2018

1 reference

α-D-Glucosyl Transfer to Phenolic Compounds by Sucrose Phosphorylase from Leuconostoc mesenteroides and Production of α-Arbutin.

21 January 2018

1 reference

Rational engineering of Lactobacillus acidophilus NCFM maltose phosphorylase into either trehalose or kojibiose dual specificity phosphorylase.

21 January 2018

1 reference

Glycosylation and the immune system

21 January 2018

1 reference

Roles of glycans and glycopeptides in immune system and immune-related diseases

21 January 2018

1 reference

Natural-product sugar biosynthesis and enzymatic glycodiversification

21 January 2018

1 reference

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

21 January 2018

1 reference

Glycosyltransferases: structures, functions, and mechanisms

21 January 2018

1 reference

New structures, chemical functions, and inhibitors for glycosyltransferases

21 January 2018

1 reference

Structures and mechanisms of glycosyltransferases

21 January 2018

1 reference

Trapping and characterization of covalent intermediates of mutant retaining glycosyltransferases.

21 January 2018

1 reference

Mechanistic insight into enzymatic glycosyl transfer with retention of configuration through analysis of glycomimetic inhibitors

21 January 2018

1 reference

Glycosyltransferase-catalyzed synthesis of bioactive oligosaccharides

21 January 2018

1 reference

Glycosyltransferases as biocatalysts

21 January 2018

1 reference

Glycosyltransferases and their Assays

21 January 2018

1 reference

Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution

21 January 2018

1 reference

A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution

21 January 2018

1 reference

High-throughput screening methodology for the directed evolution of glycosyltransferases

21 January 2018

1 reference

A high-throughput pH indicator assay for screening glycosyltransferase saturation mutagenesis libraries

21 January 2018

1 reference

Development of a universal glycosyltransferase assay amenable to high-throughput formats

21 January 2018

1 reference

Nucleotide deoxysugars: essential tools for the glycosylation engineering of novel bioactive compounds.

21 January 2018

1 reference

A survey of chemical methods for sugar-nucleotide synthesis.

21 January 2018

1 reference

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

21 January 2018

1 reference

Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

21 January 2018

1 reference

Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses

21 January 2018

1 reference

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity

21 January 2018

1 reference

Indolocarbazole antitumour compounds by combinatorial biosynthesis

21 January 2018

1 reference

Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis

21 January 2018

1 reference

Engineered Biosynthesis of Gilvocarcin Analogues with Altered Deoxyhexopyranose Moieties

21 January 2018

1 reference

Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity

21 January 2018

1 reference

An enzyme module system for the synthesis of dTDP-activated deoxysugars from dTMP and sucrose.

21 January 2018

1 reference

Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis

21 January 2018

1 reference

A two-stage one-pot enzymatic synthesis of TDP-L-mycarose from thymidine and glucose-1-phosphate

21 January 2018

1 reference

Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars

21 January 2018

1 reference

In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.

21 January 2018

1 reference

Characterization of the TDP-d-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-d-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate

21 January 2018

1 reference

Evolutionary trace analysis of the alpha-D-phosphohexomutase superfamily

21 January 2018

1 reference

Cloning of Glucuronokinase from Arabidopsis thaliana, the last missing enzyme of the myo-inositol oxygenase pathway to nucleotide sugars

21 January 2018

1 reference

Identification of galacturonic acid-1-phosphate kinase, a new member of the GHMP kinase superfamily in plants, and comparison with galactose-1-phosphate kinase

21 January 2018

1 reference

Molecular structure of galactokinase

21 January 2018

1 reference

Galactokinase: structure, function and role in type II galactosemia

21 January 2018

1 reference

The molecular architecture of human N-acetylgalactosamine kinase

21 January 2018

1 reference

Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum

21 January 2018

1 reference

Purification to Apparent Homogeneity and Properties of Pig Kidneyl-Fucose Kinase

21 January 2018

1 reference

Structure-based engineering of E. coli galactokinase as a first step toward in vivo glycorandomization

21 January 2018

1 reference

Mechanistic implications of Escherichia coli galactokinase structure-based engineering

21 January 2018

1 reference

Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives

21 January 2018

1 reference

Structure-based enhancement of the first anomeric glucokinase

21 January 2018

1 reference

Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives

21 January 2018

1 reference

A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase

21 January 2018

1 reference

Remodeling bacterial polysaccharides by metabolic pathway engineering

21 January 2018

1 reference

Molecular structure of human galactokinase: implications for type II galactosemia

21 January 2018

1 reference

Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase

21 January 2018

1 reference

Kinetic analysis of yeast galactokinase: implications for transcriptional activation of the GAL genes

21 January 2018

1 reference

Galactokinase of Vicia faba seeds

21 January 2018

1 reference

Purification and mechanism of action of a plant galactokinase

21 January 2018

1 reference

Purification and properties of galactokinase from pig liver

21 January 2018

1 reference

Sugar recognition by human galactokinase

21 January 2018

1 reference

Studies on the substrate specificity of Escherichia coli galactokinase

21 January 2018

1 reference

Recent Carbohydrate-Based Chemoselective Ligation Applications

21 January 2018

1 reference

Bioorthogonal chemistry: fishing for selectivity in a sea of functionality

21 January 2018

1 reference

Human symbionts use a host-like pathway for surface fucosylation

21 January 2018

1 reference

A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.

21 January 2018

1 reference

21 January 2018

1 reference

The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA)

21 January 2018

1 reference

Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase

21 January 2018

1 reference

Enhancing the latent nucleotide triphosphate flexibility of the glucose-1-phosphate thymidylyltransferase RmlA.

21 January 2018

1 reference

A practical enzymatic synthesis of UDP sugars and NDP glucoses

21 January 2018

1 reference

Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7.

21 January 2018

1 reference

Phosphomannose isomerase/GDP-mannose pyrophosphorylase from Pyrococcus furiosus: a thermostable biocatalyst for the synthesis of guanidinediphosphate-activated and mannose-containing sugar nucleotides.

21 January 2018

1 reference

Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering

21 January 2018

1 reference

Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization

21 January 2018

1 reference

Engineering ribonucleoside triphosphate specificity in a thymidylyltransferase.

21 January 2018

1 reference

Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution

21 January 2018

1 reference

Structure-based enzyme engineering and its impact on in vitro glycorandomization.

21 January 2018

1 reference

Flexible enzymatic and chemo-enzymatic approaches to a broad range of uridine-diphospho-sugars.

21 January 2018

1 reference

The in vitro characterization of polyene glycosyltransferases AmphDI and NysDI

21 January 2018

1 reference

UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts

21 January 2018

1 reference

Leishmania UDP-sugar pyrophosphorylase: the missing link in galactose salvage?

21 January 2018

1 reference

Application of the nucleotidylyltransferase Ep toward the chemoenzymatic synthesis of dTDP-desosamine analogues

21 January 2018

1 reference

Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization

21 January 2018

1 reference

Enzymatic synthesis of UDP-GlcNAc/UDP-GalNAc analogs using N-acetylglucosamine 1-phosphate uridyltransferase (GlmU).

21 January 2018

1 reference

Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity.

21 January 2018

1 reference

Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides

21 January 2018

1 reference

Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates

21 January 2018

1 reference

A comparison of sugar indicators enables a universal high-throughput sugar-1-phosphate nucleotidyltransferase assay

21 January 2018

1 reference

Surprising bacterial nucleotidyltransferase selectivity in the conversion of carbaglucose-1-phosphate

21 January 2018

1 reference

Strategies for the chemoenzymatic synthesis of deoxysugar nucleotides: substrate binding versus catalysis

21 January 2018

1 reference

Properties and physiological functions of UDP-sugar pyrophosphorylase in Arabidopsis

21 January 2018

1 reference

Structural Basis for the Broad Substrate Range of the UDP-Sugar Pyrophosphorylase from Leishmania major

21 January 2018

1 reference

Identification of a novel UDP-sugar pyrophosphorylase with a broad substrate specificity in Trypanosoma cruzi

21 January 2018

1 reference

One-step synthesis of labeled sugar nucleotides for protein O-GlcNAc modification studies by chemical function analysis of an archaeal protein.

21 January 2018

1 reference

Chemoenzymatic synthesis of oligosaccharides and glycoproteins

21 January 2018

1 reference

Synthesis of complex carbohydrates and glycoconjugates: enzyme-based and programmable one-pot strategies

21 January 2018

1 reference

Combined biosynthetic pathway for de novo production of UDP-galactose: catalysis with multiple enzymes immobilized on agarose beads

21 January 2018

1 reference

Sugar nucleotide regeneration beads (superbeads): a versatile tool for the practical synthesis of oligosaccharides

21 January 2018

1 reference

Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

21 January 2018

1 reference

The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility

21 January 2018

1 reference

The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification

21 January 2018

1 reference

Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis

21 January 2018

1 reference

Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products.

21 January 2018

1 reference

Single amino acid mutations of Medicago glycosyltransferase UGT85H2 enhance activity and impart reversibility.

21 January 2018

1 reference

Crystal structures of glycosyltransferase UGT78G1 reveal the molecular basis for glycosylation and deglycosylation of (iso)flavonoids

21 January 2018

1 reference

Bidirectional N-acetylglucosamine transfer mediated by beta-1,4-N-acetylglucosaminyltransferase III.

21 January 2018

1 reference

Probing the aglycon promiscuity of an engineered glycosyltransferase

21 January 2018

1 reference

Recombinant E. coli prototype strains for in vivo glycorandomization.

21 January 2018

1 reference

Genetics of Streptomyces fradiae and tylosin biosynthesis

21 January 2018

1 reference

Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis

21 January 2018

1 reference

Production of the antitumor drug epirubicin (4′-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius

21 January 2018

1 reference

Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli

21 January 2018

1 reference

Large-scale synthesis of H-antigen oligosaccharides by expressing Helicobacter pylori alpha1,2-fucosyltransferase in metabolically engineered Escherichia coli cells

21 January 2018

1 reference

Efficient synthesis of 6'-sialyllactose, 6,6'-disialyllactose, and 6'-KDO-lactose by metabolically engineered E. coli expressing a multifunctional sialyltransferase from the Photobacterium sp. JT-ISH-224.

21 January 2018

1 reference

Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of Streptomyces venezuelae

21 January 2018

1 reference

Engineering the glycosylation of natural products in actinomycetes

21 January 2018

1 reference

Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing "superbug".

21 January 2018

1 reference

Large-scale synthesis of globotriose derivatives through recombinant E. coli

21 January 2018

1 reference

Bio-fermentation of modified flavonoids: an example of in vivo diversification of secondary metabolites

21 January 2018

1 reference

Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides

21 January 2018

1 reference

Glucosylation of flavonols by Escherichia coli expressing glucosyltransferase from rice (Oryza sativa).

21 January 2018

1 reference

Selective detection of sugar phosphates by capillary electrophoresis/mass spectrometry and its application to an engineered E. coli host

21 January 2018

1 reference

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

1 reference

Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins.

21 January 2018

1 reference

Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.

21 January 2018

1 reference

Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway

21 January 2018

1 reference

The biosynthetic gene clusters of aminocoumarin antibiotics.

21 January 2018

1 reference

Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG).

21 January 2018

1 reference

Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster

21 January 2018

1 reference

A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin

21 January 2018

1 reference

AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.

21 January 2018

1 reference

Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.

21 January 2018

1 reference

Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.

21 January 2018

1 reference

AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.

21 January 2018

1 reference

Inhibition of collagenase by aranciamycin and aranciamycin derivatives

21 January 2018

1 reference

Cloning, purification and characterization of a functional anthracycline glycosyltransferase

21 January 2018

1 reference

Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans

21 January 2018

1 reference

Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin

21 January 2018

1 reference

Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.

21 January 2018

1 reference

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

21 January 2018

1 reference

Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity

21 January 2018

1 reference

Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated

21 January 2018

1 reference

Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity

21 January 2018

1 reference

The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers

21 January 2018

1 reference

Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.

21 January 2018

1 reference

Antitumor antibiotics: bleomycin, enediynes, and mitomycin

21 January 2018

1 reference

The calicheamicin gene cluster and its iterative type I enediyne PKS

21 January 2018

1 reference

Glycopeptide and lipoglycopeptide antibiotics

21 January 2018

1 reference

Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus

21 January 2018

1 reference

Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene

21 January 2018

1 reference

21 January 2018

Glycopeptide derivatives

1 reference

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

21 January 2018

1 reference

Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy

21 January 2018

1 reference

Enzymatic synthesis of vancomycin derivatives using galactosyltransferase and sialyltransferase.

21 January 2018

1 reference

Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin

21 January 2018

1 reference

Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.

21 January 2018

1 reference

Antibiotic optimization via in vitro glycorandomization

21 January 2018

1 reference

Diversifying vancomycin via chemoenzymatic strategies.

21 January 2018

1 reference

A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases

21 January 2018

1 reference

Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.

21 January 2018

1 reference

Chimeric glycosyltransferases for the generation of hybrid glycopeptides

21 January 2018

1 reference

Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

21 January 2018

1 reference

Chemical synthesis of analogs of the glycopeptide contulakin-G, an analgetically active conopeptide from Conus geographus

21 January 2018

1 reference

Follow the leader: the use of leader peptides to guide natural product biosynthesis.

21 January 2018

1 reference

Contulakin-G, an O-glycosylated invertebrate neurotensin

21 January 2018

1 reference

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Identifiers

DOI

10.1039/C1NP00045D

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