Histone deacetylase activity is required for full transcriptional repression by mSin3A (Q28238079)

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T C Fleischer

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S L Schreiber

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D E Ayer

Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death

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language of work or name

English

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publication date

2 May 1997

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published in

Cell

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volume

89

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issue

3

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page(s)

341-7

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cites work

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A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.

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Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity

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Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

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Mad proteins contain a dominant transcription repression domain.

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Transcriptional Regulation: Flipping the Myc switch

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Transcriptional silencing in yeast is associated with reduced nucleosome acetylation

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Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate

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Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation

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The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

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Yeast histone H4 N-terminal sequence is required for promoter activation in vivo

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Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogenin

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SIN3-dependent transcriptional repression by interaction with the Mad1 DNA-binding protein

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A positive role for histone acetylation in transcription factor access to nucleosomal DNA

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The transcriptional coactivators p300 and CBP are histone acetyltransferases

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The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism

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A retinoblastoma-binding protein related to a negative regulator of Ras in yeast

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Inhibition of cell proliferation by the Mad1 transcriptional repressor

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HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

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An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3

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Structure of the chicken myelomonocytic growth factor gene and specific activation of its promoter in avian myelomonocytic cells by protein kinases

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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

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Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei

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The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein

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Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4

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Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

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7 January 2021

RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae

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The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs

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Genetic interactions between SIN3 mutations and the Saccharomyces cerevisiae transcriptional activators encoded by MCM1, STE12, and SWI1

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7 January 2021

Histone deacetylase: a regulator of transcription

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Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

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7 January 2021

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

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7 January 2021

The Saccharomyces cerevisiae GAM2/SIN3 protein plays a role in both activation and repression of transcription

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7 January 2021

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

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7 January 2021