Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity (Q28235230)

Human hypertension caused by mutations in the kidney isozyme of 11β–hydroxysteroid dehydrogenase

Europe PubMed Central

title

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity (English)

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Deborah J Wake

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Brian R Walker

series ordinal

2

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language of work or name

English

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publication date

February 2006

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published in

Endocrine

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volume

29

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issue

1

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page(s)

101-8

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cites work

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12 December 2020

The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients

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12 December 2020

Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly

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The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans

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Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

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Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess

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12 December 2020

Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease

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12 December 2020

In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue

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12 December 2020

Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice

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12 December 2020

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice

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12 December 2020

Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice

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12 December 2020

Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians

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12 December 2020

A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome.

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12 December 2020

Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone.

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12 December 2020

11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver

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12 December 2020

Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver

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12 December 2020

Different responsiveness in body weight and hepatic 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 mrna to 11beta-HSD inhibition by glycyrrhetinic acid treatment in obese and lean zucker rats

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12 December 2020

Central and peripheral glucocorticoid receptor function in abdominal obesity

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12 December 2020

11 beta-Hydroxysteroid dehydrogenase

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12 December 2020

Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss

1 reference

12 December 2020

Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by growth hormone and insulin-like growth factor: in vivo and in vitro studies

1 reference

12 December 2020

Apparent cortisone reductase deficiency: a unique form of hypercortisolism

1 reference

12 December 2020

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol

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12 December 2020

Portal and peripheral cortisol levels in obese humans

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12 December 2020

Novel aspects of hormone action: intracellular ligand supply and its control by a series of tissue specific enzymes

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12 December 2020

Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum

1 reference

12 December 2020

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.

1 reference

12 December 2020

Does central obesity reflect "Cushing's disease of the omentum"?

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12 December 2020

Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase

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12 December 2020

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity

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12 December 2020

C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways

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12 December 2020

Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation

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12 December 2020

'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells.

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12 December 2020

Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice

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12 December 2020

Resistance to glucocorticoid feedback in obesity

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12 December 2020

Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus

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12 December 2020

Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation

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12 December 2020

Selective inhibition of human type 1 11beta-hydroxysteroid dehydrogenase by synthetic steroids and xenobiotics

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12 December 2020

Splanchnic cortisol production occurs in humans: evidence for conversion of cortisone to cortisol via the 11-beta hydroxysteroid dehydrogenase (11beta-hsd) type 1 pathway

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12 December 2020

Preventing local regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 enhances angiogenesis

1 reference

12 December 2020

The sequence of 5' flanking DNA from the mouse 11 beta-hydroxysteroid dehydrogenase type 1 gene and analysis of putative transcription factor binding sites

1 reference

12 December 2020

The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults.

1 reference

12 December 2020

Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments

1 reference

12 December 2020

Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application

1 reference

12 December 2020

Associations between inflammatory markers, traditional risk factors, and complications in patients with type 2 diabetes mellitus

1 reference

12 December 2020

11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated

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12 December 2020

Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity.

1 reference

12 December 2020

Independent effects of obesity and cortisol in predicting cardiovascular risk factors in men and women

1 reference

12 December 2020

11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle

1 reference

12 December 2020

Obesity and gender influence cortisol secretion and metabolism in man.

1 reference

12 December 2020

Conversion of cortisone to compound F

1 reference

12 December 2020

Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells.

1 reference

12 December 2020

Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains

1 reference

12 December 2020

Obesity and type 2 diabetes do not alter splanchnic cortisol production in humans

1 reference

12 December 2020

11 beta-Hydroxysteroid dehydrogenase 1 activity and gene expression in human adipose stromal cells: effect on aromatase activity

1 reference

12 December 2020

Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization.

1 reference

12 December 2020

Is 11beta-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats

1 reference

12 December 2020

Cortisol effects on body mass, blood pressure, and cholesterol in the general population

1 reference

12 December 2020

Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies

1 reference

12 December 2020

Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice

1 reference

12 December 2020

11 beta-Hydroxysteroid dehydrogenase activity in hypothalamic obesity

1 reference

12 December 2020

1 reference

12 December 2020

Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors

1 reference

12 December 2020

Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase

1 reference

12 December 2020

C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women

1 reference

12 December 2020

Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice

1 reference

12 December 2020

Distinguishing the activities of 11beta-hydroxysteroid dehydrogenases in vivo using isotopically labeled cortisol

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12 December 2020

1 reference

12 December 2020

11 Beta-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages

1 reference

12 December 2020

Induction of 11beta-hydroxysteroid dehydrogenase type 1 but not -2 in human aortic smooth muscle cells by inflammatory stimuli

1 reference

12 December 2020

Effect of growth hormone, insulin and dexamethasone on 11 beta-hydroxysteroid dehydrogenase activity on a primary culture of rat hepatocytes

1 reference

12 December 2020

Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism

1 reference

12 December 2020

Inhibition of 11 beta-hydroxysteroid dehydrogenase obtained from guinea pig kidney by some bioflavonoids and triterpenoids

1 reference

12 December 2020

Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.

1 reference

12 December 2020

Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins

1 reference

12 December 2020

Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase

1 reference

12 December 2020

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

1 reference

12 December 2020

Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: evidence for a central and a peripheral alteration

1 reference

12 December 2020

11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

1 reference

12 December 2020

Effect of hypercortisolism and ACTH on the metabolism of cortisol1

1 reference

12 December 2020

Influence of short-term dietary weight loss on cortisol secretion and metabolism in obese men.

1 reference

12 December 2020

Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates

1 reference

12 December 2020

Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity

1 reference

12 December 2020

Tissue-specific dysregulation of cortisol metabolism in human obesity

1 reference

12 December 2020

Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases

1 reference

12 December 2020

Local and systemic impact of transcriptional up-regulation of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity

1 reference

12 December 2020

Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats

1 reference

12 December 2020

PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.

1 reference

12 December 2020

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines

1 reference

12 December 2020

Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme

1 reference

12 December 2020

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

1 reference

12 December 2020

11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

1 reference

12 December 2020

Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity

1 reference

12 December 2020

A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells

1 reference

12 December 2020

An in vivo study of the cortisol-cortisone shuttle in subcutaneous abdominal adipose tissue

1 reference

12 December 2020

A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis

1 reference

12 December 2020

A transgenic model of visceral obesity and the metabolic syndrome

1 reference

12 December 2020

Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study

1 reference

12 December 2020

Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study

1 reference

12 December 2020

Apparent cortisone reductase deficiency: a functional defect in 11beta-hydroxysteroid dehydrogenase type 1

1 reference

12 December 2020

Insulin attenuates the stimulatory effects of tumor necrosis factor alpha on 11beta-hydroxysteroid dehydrogenase 1 in human adipose stromal cells

1 reference

12 December 2020

Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells

1 reference

12 December 2020

Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in women with visceral and subcutaneous obesity: effects of the corticotropin-releasing factor/arginine-vasopressin test and of stress

1 reference

12 December 2020

Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes.

1 reference

12 December 2020