Mucins in cancer: protection and control of the cell surface (Q28235006)

Intestinal Mucins in Health and Disease

Europe PubMed Central

title

Mucins in cancer: protection and control of the cell surface (English)

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author name string

Michael A Hollingsworth

series ordinal

1

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Benjamin J Swanson

series ordinal

2

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language of work or name

English

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publication date

January 2004

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published in

Nature Reviews Cancer

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volume

4

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issue

1

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page(s)

45-60

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cites work

1 reference

Immunochemical studies on blood groups. XXXIV. Structures of some oligosaccharides produced by alkaline degradation of blood group A, B, and H substances

31 March 2020

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Increase of blood group A and loss of blood group Sda activity in the mucus from human neoplastic colon

31 March 2020

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Blood group specificity of pancreatic tumor mucin

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Structure and function of the Ca antigen

31 March 2020

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Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium

31 March 2020

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Detection of a pancreatic cancer-associated antigen (DU-PAN-2 antigen) in serum and ascites of patients with adenocarcinoma

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Reactivity of a monoclonal antibody with human ovarian carcinoma

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A radioimmunoassay for the detection of a human tumor-associated glycoprotein (TAG-72) using monoclonal antibody B72.3.

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Isolation and characterization of MUC15, a novel cell membrane-associated mucin

31 March 2020

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MUC17, a novel membrane-tethered mucin.

31 March 2020

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Molecular cloning of cDNAs derived from a novel human intestinal mucin gene

31 March 2020

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Human mucin genes: genomic organization and expression of MUC4, MUC5AC and MUC5B

31 March 2020

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Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus

31 March 2020

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Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16.

31 March 2020

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The CA 125 gene: an extracellular superstructure dominated by repeat sequences

31 March 2020

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Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin

31 March 2020

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Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells

31 March 2020

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Subunit structure of porcine submaxillary mucin

31 March 2020

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Overexpression of MUC1 reconfigures the binding properties of tumor cells

31 March 2020

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MUC1: the polymorphic appearance of a human mucin

31 March 2020

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Cell signaling through membrane mucins

31 March 2020

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Identification of MUC1 proteolytic cleavage sites in vivo

31 March 2020

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The SEA module: a new extracellular domain associated with O-glycosylation

31 March 2020

1 reference

Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins

31 March 2020

1 reference

Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding

31 March 2020

1 reference

MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region

31 March 2020

1 reference

Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways

31 March 2020

1 reference

Form and pattern of MUC1 expression on T cells activated in vivo or in vitro suggests a function in T-cell migration.

31 March 2020

1 reference

The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin

31 March 2020

1 reference

Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland

31 March 2020

1 reference

Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family.

31 March 2020

1 reference

The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis Of the primary amino acid sequence

31 March 2020

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Human mucin genes assigned to 11p15.5: identification and organization of a cluster of genes

31 March 2020

1 reference

The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin

31 March 2020

1 reference

Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus

31 March 2020

1 reference

The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

31 March 2020

1 reference

Human MUC5AC mucin dimerizes in the rough endoplasmic reticulum, similarly to the MUC2 mucin

31 March 2020

1 reference

An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.

31 March 2020

1 reference

Evidence that a peptide corresponding to the rat Muc2 C-terminus undergoes disulphide-mediated dimerization

31 March 2020

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Human gastric mucins--a major population identified as MUC5

31 March 2020

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Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression

31 March 2020

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Viscous fingering of HCI through gastric mucin

31 March 2020

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Effects of rabbit gastrointestinal mucins and dextran on hydrochloride diffusion in vitro

31 March 2020

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pH-dependent conformational change of gastric mucin leads to sol-gel transition

31 March 2020

1 reference

Regional differences of H , HCO3-, and CO2 diffusion through native porcine gastroduodenal mucus

31 March 2020

1 reference

Tracing the evolutionary origin of the TFF-domain, an ancient motif at mucous surfaces

31 March 2020

1 reference

The trefoil peptide family

31 March 2020

1 reference

Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain

31 March 2020

1 reference

pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins

31 March 2020

1 reference

Effect of trefoil factors on the viscoelastic properties of mucus gels

31 March 2020

1 reference

Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis

31 March 2020

1 reference

The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation

31 March 2020

1 reference

Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa.

31 March 2020

1 reference

Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer.

31 March 2020

1 reference

Patterns of expression of trefoil peptides and mucins in gastric polyps with and without malignant transformation

31 March 2020

1 reference

Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo

31 March 2020

1 reference

Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure

31 March 2020

1 reference

Distribution and partial characterisation of IgG Fc binding protein in various mucin producing cells and body fluids

31 March 2020

1 reference

Recombinant human interleukins IL-1alpha, IL-1beta, IL-4, IL-6, and IL-7 show different and specific calcium-independent carbohydrate-binding properties

31 March 2020

1 reference

Interleukin-9 induces mucous cell metaplasia independent of inflammation

31 March 2020

1 reference

Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells

31 March 2020

1 reference

Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways.

31 March 2020

1 reference

Proinflammatory cytokines trigger MUC gene expression and mucin release in the intestinal cancer cell line LS180.

31 March 2020

1 reference

Growth factors and the gastrointestinal tract.

31 March 2020

1 reference

MUC7 20-Mer: investigation of antimicrobial activity, secondary structure, and possible mechanism of antifungal action

31 March 2020

1 reference

Human salivary MUC7 mucin peptides: effect of size, charge and cysteine residues on antifungal activity

31 March 2020

1 reference

New aspects of siglec binding specificities, including the significance of fucosylation and of the sialyl-Tn epitope. Sialic acid-binding immunoglobulin superfamily lectins

31 March 2020

1 reference

MUC1 mucin core protein binds to the domain 1 of ICAM-1.

31 March 2020

1 reference

Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins. Cytokine receptor-like molecules.

31 March 2020

1 reference

Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion

31 March 2020

1 reference

Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion

31 March 2020

1 reference

Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin

31 March 2020

1 reference

Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin.

31 March 2020

1 reference

The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)

31 March 2020

1 reference

Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling

31 March 2020

1 reference

MUC4 expression increases progressively in pancreatic intraepithelial neoplasia

31 March 2020

1 reference

Extracellular regulated kinase (ERK)-dependent regulation of sialomucin complex/rat Muc4 in mammary epithelial cells

31 March 2020

1 reference

Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor

31 March 2020

1 reference

Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive

31 March 2020

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Colorectal cancer in mice genetically deficient in the mucin Muc2

31 March 2020

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MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients

31 March 2020

1 reference

Expression of mucin antigens in human cancers and its relationship with malignancy potential

31 March 2020

1 reference

Delayed mammary tumor progression in Muc-1 null mice.

31 March 2020

1 reference

MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma

31 March 2020

1 reference

Immunoreactive MUC1 expression at the deepest invasive portion correlates with prognosis of colorectal cancer

31 March 2020

1 reference

The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas

31 March 2020

1 reference

Immunohistochemical study of MUC1 mucin in premalignant oral lesions and oral squamous cell carcinoma: association with disease progression, mode of invasion, and lymph node metastasis

31 March 2020

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The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature

31 March 2020

1 reference

Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components

31 March 2020

1 reference

A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1.

31 March 2020

1 reference

Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin

31 March 2020

1 reference

Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis

31 March 2020

1 reference

Migration of helper T-lymphocyte subsets into inflamed tissues

31 March 2020

1 reference

Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium

31 March 2020

1 reference

Regulatory roles of carbohydrate ligands for selectins in the homing of lymphocytes.

31 March 2020

1 reference

Soluble MUC1 secreted by human epithelial cancer cells mediates immune suppression by blocking T-cell activation

31 March 2020

1 reference

Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells

31 March 2020

1 reference

Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2

31 March 2020

1 reference

The biological role of mucins in cellular interactions and immune regulation: prospects for cancer immunotherapy

31 March 2020

1 reference

Usefulness of novel tumour markers

31 March 2020

1 reference

Differences in expression of SPan-1 and CA15-3 antigens in blood and tissues

31 March 2020

1 reference

Evaluation of five glycoprotein tumour markers (CEA, CA-50, CA-19-9, CA-125, CA-15-3) for the prognosis of renal-cell carcinoma

31 March 2020

1 reference

CA 19.9, CA 242 and CEA in the diagnosis and follow-up of pancreatic cancer

31 March 2020

1 reference

Clinical evaluation of pancreatic cancer-associated mucin expressing CA19-9, CA50, Span-1, sialyl SSEA-1, and Dupan-2.

31 March 2020

1 reference

The prognostic significance of sialyl-Tn antigen in women treated with breast carcinoma treated with adjuvant chemotherapy

31 March 2020

1 reference

MUC1: antibodies and immunoassays

31 March 2020

1 reference

New immunoassays for MUC1 in breast cancer

31 March 2020

1 reference

Expression of MUC1, MUC2, MUC3 and MUC4 mucin mRNAs in human pancreatic and intestinal tumor cell lines

31 March 2020

1 reference

Oligosaccharides expressed on MUC1 produced by pancreatic and colon tumor cell lines

31 March 2020

1 reference

Developmental expression of mucin genes in the human gastrointestinal system

31 March 2020

1 reference

Developmental expression of mucin genes in the human respiratory tract.

31 March 2020

1 reference

Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene

31 March 2020

1 reference

The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure

31 March 2020

1 reference

Expression of core 2 beta-1,6-N-acetylglucosaminyltransferase in a human pancreatic cancer cell line results in altered expression of MUC1 tumor-associated epitopes

31 March 2020

1 reference

Clinical Pharmacology, Metabolism, and Tissue Distribution of 90Y-Labeled Monoclonal Antibody B72.3 After Intraperitoneal Administration

31 March 2020

1 reference

Radioimmunodetection and Radioimmunotherapy of Breast Cancer

31 March 2020

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Systemic radiotherapy in metastatic breast cancer using 90Y-linked monoclonal MUC-1 antibodies

31 March 2020

1 reference

Combined gemcitabine and radioimmunotherapy for the treatment of pancreatic cancer

31 March 2020

1 reference

Induction of CA125-specific B and T cell responses in patients injected with MAb-B43.13--evidence for antibody-mediated antigen-processing and presentation of CA125 in vivo

31 March 2020

1 reference

Mucin gene (MUC1) transfected dendritic cells as vaccine: results of a phase I/II clinical trial

31 March 2020

1 reference

A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma

31 March 2020

1 reference

Reevaluation of the cellular immune response in breast cancer patients vaccinated with MUC1

31 March 2020

1 reference

Anti-MUC1 class I restricted CTLs in metastatic breast cancer patients immunized with a synthetic MUC1 peptide

31 March 2020

1 reference

Chemoenzymatic synthesis of sialylated glycopeptides derived from mucins and T-cell stimulating peptides

31 March 2020

1 reference

Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein

31 March 2020

1 reference

Vaccines prepared with sialyl-Tn and sialyl-Tn trimers using the 4-(4-maleimidomethyl)cyclohexane-1-carboxyl hydrazide linker group result in optimal antibody titers against ovine submaxillary mucin and sialyl-Tn-positive tumor cells

31 March 2020

1 reference

A randomised phase II study of sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer

31 March 2020

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Immunogenicity of synthetic TF-KLH (keyhole limpet hemocyanin) and sTn-KLH conjugates in colorectal carcinoma patients

31 March 2020

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On the power of chemical synthesis: immunological evaluation of models for multiantigenic carbohydrate-based cancer vaccines.

31 March 2020

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Clinical tumour markers in lung cancer

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Enhancing the effect of THERATOPE STn-KLH cancer vaccine in patients with metastatic breast cancer by pretreatment with low-dose intravenous cyclophosphamide

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1251

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1052855187

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Fatcat ID

release_pdq5f5ovvzcxbon4woljind3o4

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Fatcat

https://api.fatcat.wiki/v0/release/pdq5f5ovvzcxbon4woljind3o4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

14681689

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Consolidated OpenCitations Corpus – April 2017