Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition (Q28212407)

Europe PubMed Central

title

Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition (English)

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6

Ravi Salgia

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author name string

Gautam Maulik

1

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Amol Shrikhande

2

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Takashi Kijima

3

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Patrick C Ma

4

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Paul T Morrison

Cytokine and Growth Factor Reviews

5

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language of work or name

English

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publication date

February 2002

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published in

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volume

13

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issue

1

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page(s)

41-59

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cites work

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Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

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Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis

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Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists

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A Peptide Representing the Carboxyl-terminal Tail of the Met Receptor Inhibits Kinase Activity and Invasive Growth

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Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

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Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

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c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells

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Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src.

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The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

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An 11-amino acid sequence from c-met initiates epithelial chemotaxis via phosphatidylinositol 3-kinase and phospholipase C.

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

11750879

1 reference

Consolidated OpenCitations Corpus – April 2017