A search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolution (Q28211367)

Histochemistry and Cell Biology

Europe PubMed Central

title

A search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolution (English)

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1

Charles N Serhan

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language of work or name

English

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publication date

October 2004

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published in

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volume

122

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issue

4

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page(s)

305-21

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cites work

Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis

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Crossref

https://api.crossref.org/works/10.1007/S00418-004-0695-8

Mechanisms of action of docosahexaenoic acid in the nervous system

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Lipoxins: pro-resolution lipid mediators in intestinal inflammation

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12 December 2020

Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity?

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12 December 2020

Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation

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12 December 2020

Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid

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12 December 2020

Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense.

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12 December 2020

Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients

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12 December 2020

A novel rat lipoxin A4 receptor that is conserved in structure and function

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12 December 2020

Potential vascular roles for lipoxins in the “stop programs” of host defense and inflammation

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12 December 2020

Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression

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12 December 2020

15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure

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12 December 2020

Biomedicine. Back to an aspirin a day?

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12 December 2020

Treatment of asthma with drugs modifying the leukotriene pathway.

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12 December 2020

Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils

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12 December 2020

Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA.

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12 December 2020

Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils

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12 December 2020

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

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12 December 2020

Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils

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12 December 2020

Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics

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12 December 2020

P-selectin mediates the interaction of circulating leukocytes with platelets and microvascular endothelium in response to oxidized lipoprotein in vivo

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12 December 2020

Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione.

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12 December 2020

Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling

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12 December 2020

Physical exercise increases urinary excretion of lipoxin A4 and related compounds

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12 December 2020

Leukotrienes, sphingolipids, and leukocyte trafficking

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12 December 2020

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

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12 December 2020

Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases

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12 December 2020

Imbalance between lipoxin A4 and leukotriene B4 in chronic mastitis-affected cows

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12 December 2020

Urinary excretion of lipoxin A(4) and related compounds: development of new extraction techniques for lipoxins

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12 December 2020

Lipid mediator class switching during acute inflammation: signals in resolution.

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12 December 2020

Relative contribution of acetylated cyclooxygenase (COX)‐2 and 5‐lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin

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12 December 2020

A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation

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12 December 2020

Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion

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12 December 2020

Association of cystic fibrosis with abnormalities in fatty acid metabolism.

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12 December 2020

Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro

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12 December 2020

Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation

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12 December 2020

Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors

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12 December 2020

Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene

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12 December 2020

Release of inflammatory mediators from stimulated neutrophils.

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12 December 2020

Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking

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12 December 2020

Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis

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12 December 2020

C-reactive protein and the risk of incident colorectal cancer

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12 December 2020

Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia

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12 December 2020

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

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12 December 2020

Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation.

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12 December 2020

Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa

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12 December 2020

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms

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12 December 2020

Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4).

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12 December 2020

Is C-reactive protein an inflammation opsonin that signals colon cancer risk?

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12 December 2020

Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes

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12 December 2020

Leukotrienes and lipoxins: structures, biosynthesis, and biological effects

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12 December 2020

The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase

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12 December 2020

The development of COX2 inhibitors

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12 December 2020

Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4).

1 reference

12 December 2020

COX-2 selective nonsteroidal anti-Inflammatory drugs: do they really offer any advantages?

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12 December 2020

Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection

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12 December 2020

Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy

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12 December 2020

Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin

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12 December 2020

Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases

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12 December 2020

Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R

1 reference

12 December 2020

Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: conversion to novel 15-oxo and dihydro products

1 reference

12 December 2020

Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo

1 reference

12 December 2020

An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile

1 reference

12 December 2020

Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways

1 reference

12 December 2020

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).

1 reference

12 December 2020

Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo

1 reference

12 December 2020

Aspirin (ASA) regulates 5-lipoxygenase activity and peroxisome proliferator-activated receptor alpha-mediated CINC-1 release in rat liver cells: novel actions of lipoxin A4 (LXA4) and ASA-triggered 15-epi-LXA4

1 reference

12 December 2020

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues

1 reference

12 December 2020

Endogenous anti-inflammatory mediators from arachidonate in human neutrophils

1 reference

12 December 2020

Lipoxin A4Analogues Inhibit Leukocyte Recruitment toPorphyromonas gingivalis: A Role for Cyclooxygenase-2 and Lipoxins in Periodontal Disease†

1 reference

12 December 2020

Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage

1 reference

12 December 2020

Lipoxin biosynthesis by trout macrophages involves the formation of epoxide intermediates

1 reference

12 December 2020

Role of G-protein-coupled signaling in the induction and regulation of dendritic cell function by Toxoplasma gondii

1 reference

12 December 2020

Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis

1 reference

12 December 2020

Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators

1 reference

12 December 2020

A magic bullet for mucosal protection...and aspirin is the trigger!

1 reference

12 December 2020

Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia

1 reference

12 December 2020

Lipoxygenation of docosahexaenoic acid by the rat pineal body.

1 reference

12 December 2020

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico

1 reference

12 December 2020

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

1 reference

12 December 2020

Activation of the fatty acid alpha-dioxygenase pathway during bacterial infection of tobacco leaves. Formation of oxylipins protecting against cell death

1 reference

12 December 2020

On the Specificity of the Oxygenation of Unsaturated Fatty Acids Catalyzed by Soybean Lipoxidase

1 reference

12 December 2020

Targeting inflammatory diseases via apoptotic mechanisms.

1 reference

12 December 2020

Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.

1 reference

12 December 2020

Identification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase.

1 reference

12 December 2020

Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation

1 reference

12 December 2020

Lipoxin-stable analogs: potential therapeutic downregulators of intestinal inflammation.

1 reference

12 December 2020

Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

1 reference

12 December 2020

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells

1 reference

12 December 2020

Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors

1 reference

12 December 2020

Lipoxins: revelations on resolution

1 reference

12 December 2020

Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity

1 reference

12 December 2020

Diets could prevent many diseases

1 reference

12 December 2020

Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog.

1 reference

12 December 2020

Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils

1 reference

12 December 2020

Role of prostacyclin in the cardiovascular response to thromboxane A2

1 reference

12 December 2020

Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction

1 reference

12 December 2020

Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation

1 reference

12 December 2020

Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence

1 reference

12 December 2020

Anti-inflammatory lipid mediators and insights into the resolution of inflammation

1 reference

12 December 2020

Workshop on the Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids

1 reference

12 December 2020

Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium

1 reference

12 December 2020

Oxidation of docosahexaenoic acid by rat liver microsomes

1 reference

12 December 2020

Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia

1 reference

12 December 2020

Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release

1 reference

12 December 2020

Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis

1 reference

12 December 2020

Points of control in inflammation

1 reference

12 December 2020

Cyclooxygenase-2 inhibitors: promise or peril?

1 reference

12 December 2020

Changes in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils. Relationship to calcium mobilization, aggregation and superoxide radical generation

1 reference

12 December 2020

Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor

1 reference

12 December 2020

Lipoxin A4 stimulates a cytosolic Ca2 increase in human bronchial epithelium.

1 reference

12 December 2020

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

1 reference

12 December 2020

Lipoxins are potential endogenous antiinflammatory mediators in asthma

1 reference

12 December 2020

Fat-1 mice convert n-6 to n-3 fatty acids

1 reference

12 December 2020

Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis

1 reference

12 December 2020

Structure-based drug design: applications in immunopharmacology and immunosuppression

1 reference

12 December 2020

Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly

1 reference

12 December 2020

Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing

1 reference

12 December 2020

Lipoxin biosynthesis and its impact in inflammatory and vascular events

1 reference

12 December 2020

Inducible cyclooxygenase may have anti-inflammatory properties

1 reference

12 December 2020

Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor

1 reference

12 December 2020

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions

1 reference

12 December 2020

Lipoxins in chronic inflammation

1 reference

12 December 2020

10.1007/S00418-004-0695-8

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

15322859

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Consolidated OpenCitations Corpus – April 2017