Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 (Q28210189)

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author name string

Thomas G Hofmann

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Andreas Möller

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Hüaeyin Sirma

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Yoichi Taya

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Wulf Dröge

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Hans Will

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M Lienhard Schmitz

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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language of work or name

English

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publication date

January 2002

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published in

Nature Cell Biology

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volume

4

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issue

1

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page(s)

1-10

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cites work

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Mdm2 promotes the rapid degradation of p53

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Regulation of p53 stability by Mdm2

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Regulation of the p53 tumor suppressor protein

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Identification and classification of p53-regulated genes

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

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Stress signals utilize multiple pathways to stabilize p53

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

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Post-translational modifications and activation of p53 by genotoxic stresses

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

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DNA-dependent protein kinase-independent activation of p53 in response to DNA damage

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Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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1 reference

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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DNA damage activates p53 through a phosphorylation-acetylation cascade

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Deacetylation of p53 modulates its effect on cell growth and apoptosis

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

21 January 2018

1 reference

Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.

21 January 2018

1 reference

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

21 January 2018

1 reference

Characterization of a novel serine/threonine kinase associated with nuclear bodies

21 January 2018

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Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.

21 January 2018

1 reference

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling

21 January 2018

1 reference

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Review: properties and assembly mechanisms of ND10, PML bodies, or PODs

21 January 2018

1 reference

The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body

21 January 2018

1 reference

Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA

21 January 2018

1 reference

Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones

21 January 2018

1 reference

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.

21 January 2018

1 reference

PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia

21 January 2018

1 reference

Oncogenic forms of p53 inhibit p53-regulated gene expression

21 January 2018

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Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

21 January 2018

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Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex

21 January 2018

1 reference

Stress-activated kinases regulate protein stability

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7 January 2021

The function of PML in p53-dependent apoptosis

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7 January 2021

P53 and PML: new partners in tumor suppression

1 reference

7 January 2021

Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents

1 reference

7 January 2021