Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha (Q28208587)

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N Oshiro

3

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S Ueoku

4

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K Yoshino

5

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C Tokunaga

6

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Y Shirai

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N Saito

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I Gout

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K Yonezawa

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

10

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language of work or name

English

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publication date

November 2001

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published in

Genes to Cells

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volume

6

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issue

11

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page(s)

1003-15

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cites work

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

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Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

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Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt

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Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

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Characterization of S6K2, a novel kinase homologous to S6K1

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Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway

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Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

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Phosphorylation and activation of p70s6k by PDK1

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Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases

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TOR, a central controller of cell growth

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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Insulin signal transduction through protein kinase cascades

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Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

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Differential subcellular localisation of two isoforms of p70 S6 protein kinase.

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Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

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Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

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Regulation of eIF-4E BP1 phosphorylation by mTOR.

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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily

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Drosophila S6 kinase: a regulator of cell size

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Dual requirement for a newly identified phosphorylation site in p70s6k

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Bidirectional modulation of insulin action by amino acids

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Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

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Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

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Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

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Multiple independent inputs are required for activation of the p70 S6 kinase

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Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies

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