Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2 (Q28207477)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12085228 AND SRC:MED&resulttype=core&format=json

10 November 2019

title

Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2 (English)

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10 November 2019

2

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10 November 2019

author name string

Paula A Clark

series ordinal

1

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10 November 2019

Gordon Peters

series ordinal

3

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10 November 2019

language of work or name

English

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publication date

1 July 2002

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10 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12085228 AND SRC:MED&resulttype=core&format=json

10 November 2019

volume

21

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10 November 2019

issue

29

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10 November 2019

page(s)

4498-4507

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Regulation of p53 stability

10 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1205558

Defining the molecular basis of Arf and Hdm2 interactions

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Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer

21 January 2018

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Solution structure of the p53 regulatory domain of the p19Arf tumor suppressor protein

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Human ARF binds E2F1 and inhibits its transcriptional activity.

21 January 2018

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The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

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p53, the cellular gatekeeper for growth and division

21 January 2018

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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

21 January 2018

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An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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The MDM2 gene amplification database

21 January 2018

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The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

21 January 2018

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

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Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.

21 January 2018

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A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.

21 January 2018

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The INK4A/ARF locus and its two gene products

21 January 2018

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Tumor surveillance via the ARF-p53 pathway.

21 January 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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21 January 2018

Surfing the p53 network

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Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

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Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

21 January 2018

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

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ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

21 January 2018

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A matter of life and cell death

21 January 2018

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7 January 2021

Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus

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7 January 2021

Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization

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7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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7 January 2021

The p16INK4a/CDKN2A tumor suppressor and its relatives.

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7 January 2021

p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205558

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12085228 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 November 2019

1002727995

0 references

1 reference