DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1 (Q28205415)

GOA release 2020-03-11

author name string

Kenneth Wu

1

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Kosj Yamoah

2

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Georgia Dolios

3

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Tudeviin Gan-Erdene

4

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Peilin Tan

5

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Angus Chen

6

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Chee-Gun Lee

7

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Ning Wei

8

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Keith D Wilkinson

9

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Rong Wang

10

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Zhen-Qiang Pan

Journal of Biological Chemistry

11

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language of work or name

English

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publication date

1 August 2003

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published in

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volume

278

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issue

31

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page(s)

28882-91

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cites work

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The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

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Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

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Covalent modification of all members of human cullin family proteins by NEDD8

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Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway

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The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

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Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

21 January 2018

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A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

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Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

21 January 2018

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The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation

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An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

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Emerging roles of ubiquitin in transcription regulation

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Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M302888200

The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34

21 January 2018

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Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

21 January 2018

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NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

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The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation

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NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

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CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

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Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

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In vitro replication of duplex circular DNA containing the simian virus 40 DNA origin site

21 January 2018

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CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex

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Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes

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Reconstitution of human replication factor C from its five subunits in baculovirus-infected insect cells

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A new protease required for cell-cycle progression in yeast

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Cleavage of the C-terminus of NEDD8 by UCH-L3.

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M302888200

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 Å resolution

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M302888200

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M302888200

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M302888200

The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M302888200

Identification and characterization of DEN1, a deneddylase of the ULP family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M302888200

Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M302888200

There's the rub: a novel ubiquitin-like modification linked to cell cycle regulation

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M302888200

21 January 2018

Identifiers

DOI

10.1074/JBC.M302888200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12759363

1 reference

Consolidated OpenCitations Corpus – April 2017