Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage (Q28204752)

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Robert J Smith

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Alan J Grodzinsky

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Nora Szasz

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Stephen B Trippel

Journal of Biological Chemistry

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language of work or name

English

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publication date

19 December 2003

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published in

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volume

278

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issue

51

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page(s)

50940-8

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cites work

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The stress-activated protein kinase pathways

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Signaling by dual specificity kinases

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Transport and binding of insulin-like growth factor I through articular cartilage

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Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes

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Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules

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Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration

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Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression

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Chondrocyte cells respond mechanically to compressive loads

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Time-dependent changes in the response of cartilage to static compression suggest interstitial pH is not the only signaling mechanism

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Control of matrix synthesis in isolated bovine chondrocytes by extracellular and intracellular pH

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Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose

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Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes

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Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization

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PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

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Effect of somatomedin-C/insulin-like growth factor I and growth hormone on cultured growth plate and articular chondrocytes

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The effects of IL-1 on mitogen-activated protein kinases in rabbit articular chondrocytes

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Effects of interleukin-1 and lipopolysaccharides on protein and carbohydrate metabolism in bovine articular cartilage organ cultures

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