DNA double-strand breaks: signaling, repair and the cancer connection (Q28204231)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11242102 AND SRC:MED&resulttype=core&format=json

5 November 2019

review article

1 reference

title

DNA double-strand breaks: signaling, repair and the cancer connection (English)

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5 November 2019

2

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5 November 2019

author name string

Khanna KK

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11242102 AND SRC:MED&resulttype=core&format=json

5 November 2019

language of work or name

English

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publication date

1 March 2001

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11242102 AND SRC:MED&resulttype=core&format=json

5 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11242102 AND SRC:MED&resulttype=core&format=json

5 November 2019

volume

27

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5 November 2019

issue

3

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5 November 2019

page(s)

247-254

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Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

5 November 2019

cites work

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7 January 2021

Defying death after DNA damage.

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7 January 2021

Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells

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7 January 2021

On the role of DNA double-strand breaks in toxicity and carcinogenesis

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7 January 2021

Frequent chromosomal translocations induced by DNA double-strand breaks

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7 January 2021

Partners and pathwaysrepairing a double-strand break.

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7 January 2021

DNA double strand break repair in mammalian cells

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7 January 2021

Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

1 reference

7 January 2021

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

1 reference

7 January 2021

Rad51 accumulation at sites of DNA damage and in postreplicative chromatin

1 reference

7 January 2021

XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages

1 reference

7 January 2021

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

1 reference

7 January 2021

Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer

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7 January 2021

Mutations in the RAD54 recombination gene in primary cancers

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7 January 2021

Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation

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7 January 2021

Gatekeepers of recombination

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7 January 2021

Insights into the functions of BRCA1 and BRCA2.

1 reference

7 January 2021

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

1 reference

7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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7 January 2021

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

1 reference

7 January 2021

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

1 reference

7 January 2021

Frequency of p53 mutations in breast carcinomas from Ashkenazi Jewish carriers of BRCA1 mutations

1 reference

7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

7 January 2021

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

7 January 2021

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

1 reference

7 January 2021

Cancer risk and the ATM gene: a continuing debate

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7 January 2021

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

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7 January 2021

The controlling role of ATM in homologous recombinational repair of DNA damage

1 reference

7 January 2021

ATM: a mediator of multiple responses to genotoxic stress

1 reference

7 January 2021

Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.

1 reference

7 January 2021

Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment

1 reference

7 January 2021

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

1 reference

7 January 2021

RecQ family helicases: roles in cancer and aging

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7 January 2021

The DNA-dependent protein kinase

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7 January 2021

The Mre11 complex and ATM: collaborating to navigate S phase

1 reference

7 January 2021

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

1 reference

7 January 2021

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

1 reference

7 January 2021

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

1 reference

7 January 2021

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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7 January 2021

ATM-dependent phosphorylation of nibrin in response to radiation exposure

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7 January 2021

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

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7 January 2021

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

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7 January 2021

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

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7 January 2021

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

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7 January 2021

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

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7 January 2021

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

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7 January 2021

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

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7 January 2021

Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development

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7 January 2021

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

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7 January 2021

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

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7 January 2021

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

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7 January 2021

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

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7 January 2021

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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7 January 2021

DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints

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7 January 2021

Substrate specificities and identification of putative substrates of ATM kinase family members

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7 January 2021

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

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7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

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7 January 2021

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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7 January 2021

Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

1 reference

7 January 2021

BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression

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7 January 2021

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

1 reference

7 January 2021

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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7 January 2021

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1 reference

7 January 2021

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

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7 January 2021

The G2-phase DNA-damage checkpoint

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7 January 2021

The G(2) checkpoint is maintained by redundant pathways

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7 January 2021

Checkpoints: How to activate p53

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7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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7 January 2021

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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7 January 2021

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

1 reference

7 January 2021

Identifiers

DOI

10.1038/85798

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11242102 AND SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017