CD44: from adhesion molecules to signalling regulators (Q28201701)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

CD44: from adhesion molecules to signalling regulators (English)

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author name string

Helmut Ponta

series ordinal

1

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Larry Sherman

series ordinal

2

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Peter A Herrlich

series ordinal

3

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language of work or name

English

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publication date

January 2003

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published in

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volume

4

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issue

1

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page(s)

33-45

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cites work

Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members

1 reference

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons

31 March 2020

1 reference

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

31 March 2020

1 reference

Forms and functions of CD44.

31 March 2020

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Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression.

31 March 2020

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Variant exons v6 and v7 together expand the repertoire of glycosaminoglycans bound by CD44

31 March 2020

1 reference

Glycosylation provides both stimulatory and inhibitory effects on cell surface and soluble CD44 binding to hyaluronan

31 March 2020

1 reference

Antibody‐induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody

31 March 2020

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CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration

31 March 2020

1 reference

Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator

31 March 2020

1 reference

Regulation of alternative pre-mRNA splicing by the ERK MAP-kinase pathway

31 March 2020

1 reference

CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor

31 March 2020

1 reference

A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth

31 March 2020

1 reference

CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling

31 March 2020

1 reference

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons

31 March 2020

1 reference

Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44.

31 March 2020

1 reference

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2

31 March 2020

1 reference

Regulation of CD44-protein 4.1 interaction by Ca2 and calmodulin. Implications for modulation of CD44-ankyrin interaction

31 March 2020

1 reference

A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility

31 March 2020

1 reference

Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells

31 March 2020

1 reference

Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells

31 March 2020

1 reference

Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

31 March 2020

1 reference

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

31 March 2020

1 reference

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

31 March 2020

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p21-activated kinase links Rac/Cdc42 signaling to merlin

31 March 2020

1 reference

Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli

31 March 2020

1 reference

A crucial role for CD44 in inflammation

31 March 2020

1 reference

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

31 March 2020

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Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).

31 March 2020

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Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation

31 March 2020

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Cutaneous delayed-type hypersensitivity response is inhibited in transgenic mice with keratinocyte-specific CD44 expression defect

31 March 2020

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CD44-deficient mice exhibit enhanced hepatitis after concanavalin A injection: evidence for involvement of CD44 in activation-induced cell death

31 March 2020

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CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells

31 March 2020

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Resolution of lung inflammation by CD44

31 March 2020

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The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation

31 March 2020

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Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors

31 March 2020

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Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins.

31 March 2020

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Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G proteins

31 March 2020

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The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan

31 March 2020

1 reference

Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion

31 March 2020

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Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function

31 March 2020

1 reference

Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met

31 March 2020

1 reference

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

31 March 2020

1 reference

Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor

31 March 2020

1 reference

Role of hyaluronan and CD44 in in vitro branching morphogenesis of ureteric bud cells

31 March 2020

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Variant isoforms of CD44 are required in early thymocyte development

31 March 2020

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N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling

31 March 2020

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CD44 is required for two consecutive steps in HGF/c-Met signaling.

31 March 2020

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Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo

31 March 2020

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Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation

31 March 2020

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CD44 enhances neuregulin signaling by Schwann cells

31 March 2020

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Multiple essential functions of neuregulin in development

31 March 2020

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Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

31 March 2020

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Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein

31 March 2020

1 reference

Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl

31 March 2020

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CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration

31 March 2020

1 reference

Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowth

31 March 2020

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CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration

31 March 2020

1 reference

Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth

31 March 2020

1 reference

Involvement of CD44 in matrix metalloproteinase-2 regulation in human melanoma cells

31 March 2020

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Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia

31 March 2020

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CD44 stimulation down-regulates Fas expression and Fas-mediated apoptosis of lung cancer cells

31 March 2020

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CD44 variant-specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophages

31 March 2020

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Signaling through CD44 is mediated by tyrosine kinases. Association with p56lck in T lymphocytes

31 March 2020

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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

31 March 2020

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An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function

31 March 2020

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The impact of c-met/scatter factor receptor on dendritic cell migration

31 March 2020

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Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

31 March 2020

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Stress-activated protein kinases are negatively regulated by cell density.

31 March 2020

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Differential usage of signal transduction pathways defines two types of serum response factor target gene

31 March 2020

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A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission

31 March 2020

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A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

31 March 2020

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Participation in normal immune responses of a metastasis-inducing splice variant of CD44

31 March 2020

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Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44

31 March 2020

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Heterogeneous ribonucleoprotein A1 is part of an exon-specific splice-silencing complex controlled by oncogenic signaling pathways

31 March 2020

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Signal-dependent regulation of splicing via phosphorylation of Sam68

31 March 2020

1 reference

ERM proteins and merlin: integrators at the cell cortex

31 March 2020

1 reference

ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling

31 March 2020

1 reference

Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H( ) translocation

31 March 2020

1 reference

Layilin, a novel integral membrane protein, is a hyaluronan receptor

31 March 2020

1 reference

Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins

31 March 2020

1 reference

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

31 March 2020

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Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

31 March 2020

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Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

31 March 2020

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Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein

31 March 2020

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CD44 as a receptor for colonization of the pharynx by group A Streptococcus

31 March 2020

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CD44 binds to the Shigella IpaB protein and participates in bacterial invasion of epithelial cells

31 March 2020

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InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase

31 March 2020

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Intracellular pathogens and the actin cytoskeleton

31 March 2020

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The isolated comet tail pseudopodium of Listeria monocytogenes: a tail of two actin filament populations, long and axial and short and random.

31 March 2020

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CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation.

31 March 2020

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Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway

31 March 2020

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Expression of CD44 is repressed in neuroblastoma cells

31 March 2020

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CD44 and CD44v6 downregulation in clinical prostatic carcinoma: relation to Gleason grade and cytoarchitecture.

31 March 2020

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The BRG-1 subunit of the SWI/SNF complex regulates CD44 expression

31 March 2020

1 reference

Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression.

31 March 2020

1 reference

Hyaluronan: its nature, distribution, functions and turnover

31 March 2020

1 reference

Identification of the hyaluronan receptor for endocytosis (HARE)

31 March 2020

1 reference

LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan

31 March 2020

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Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium

31 March 2020

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Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

31 March 2020

1 reference

Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility [published erratum appears in J Cell Biol 1992 Aug;118(3):753]

31 March 2020

1 reference

Problems with RHAMM: a new link between surface adhesion and oncogenesis?

31 March 2020

1 reference

Molecular characterization of a novel intracellular hyaluronan-binding protein

31 March 2020

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Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites

31 March 2020

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Angiogenesis induced by degradation products of hyaluronic acid.

31 March 2020

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Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44.

31 March 2020

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Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments

31 March 2020

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Activation and transforming growth factor-beta production in eosinophils by hyaluronan

31 March 2020

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Hyaluronan: polysaccharide chaos to protein organisation

31 March 2020

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Characterization of a functional hyaluronan-binding domain from the human CD44 molecule expressed in Escherichia coli

31 March 2020

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Identification of CD44 residues important for hyaluronan binding and delineation of the binding site

31 March 2020

1 reference