TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation (Q28199064)

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H R Wang

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C G Causing

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P Kavsak

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S L Stroschein

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K Luo

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J L Wrana

Signal transduction by members of the transforming growth factor-beta superfamily

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language of work or name

English

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publication date

June 2001

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published in

Nature Cell Biology

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volume

3

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issue

6

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page(s)

587-95

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cites work

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TGF-β signalling from cell membrane to nucleus through SMAD proteins

21 January 2018

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TGF-beta signal transduction

21 January 2018

1 reference

Smads: transcriptional activators of TGF-beta responses

21 January 2018

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TGF-beta signaling by Smad proteins

21 January 2018

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Regulation of Smad activity

21 January 2018

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MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

21 January 2018

1 reference

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

21 January 2018

1 reference

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

21 January 2018

1 reference

Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

21 January 2018

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Smads as transcriptional co-modulators

21 January 2018

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A Smad transcriptional corepressor

21 January 2018

1 reference

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

21 January 2018

1 reference

c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

21 January 2018

1 reference

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

21 January 2018

1 reference

Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling

21 January 2018

1 reference

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

21 January 2018

1 reference

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor

21 January 2018

1 reference

21 January 2018

1 reference

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

Smad6 inhibits signalling by the TGF-β superfamily

21 January 2018

1 reference

21 January 2018

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SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

1 reference

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

21 January 2018

1 reference

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

1 reference

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

21 January 2018

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Ubiquitin-dependent degradation of TGF-beta-activated smad2.

21 January 2018

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

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The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 January 2018

1 reference

The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 January 2018

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Ubiquitin and the control of protein fate in the secretory and endocytic pathways

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/35078562

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1024085846

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Fatcat ID

release_igygemjyizhqxbhjqzkyr4yjme

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/igygemjyizhqxbhjqzkyr4yjme

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

11389444

1 reference

Consolidated OpenCitations Corpus – April 2017