Alzheimer's disease: the cholesterol connection (Q28186482)

New frontiers in Alzheimer's disease genetics

Europe PubMed Central

title

Alzheimer's disease: the cholesterol connection (English)

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Rudolph E Tanzi

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author name string

Luigi Puglielli

series ordinal

1

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Dora M Kovacs

series ordinal

3

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language of work or name

English

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publication date

April 2003

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published in

Nature Neuroscience

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volume

6

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issue

4

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page(s)

345-51

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cites work

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

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Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

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Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner

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Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

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Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

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Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

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The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in

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Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels

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Effects of apolipoprotein E genotype on blood lipid composition and membrane platelet fluidity in Alzheimer’s disease

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The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton

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A detergent-insoluble membrane compartment contains A beta in vivo

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranes

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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The role of cholesterol in the biosynthesis of beta-amyloid

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Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

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Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

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Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

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Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease?

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