Drugs from the deep: marine natural products as drug candidates (Q28181444)

Drugs from the seas - current status and microbiological implications

Europe PubMed Central

title

Drugs from the deep: marine natural products as drug candidates (English)

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main subject

marine natural product

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1 reference

Burkhard Haefner

1

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language of work or name

English

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publication date

15 June 2003

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published in

Drug Discovery Today

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volume

8

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issue

12

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page(s)

536-44

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cites work

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Conotoxins - new vistas for peptide therapeutics

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Cone venom--from accidental stings to deliberate injection

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

An evaluation of intrathecal ziconotide for the treatment of chronic pain

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

The chemistry and biology of the bryostatin antitumour macrolides

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

The clinical development of the bryostatins

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Total Synthesis of Bryostatin 2

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Synthesis of bryostatin 7

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite ( )-aeroplysinin-1

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Marine sponge polyketide inhibitors of protein tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

The marine natural product, halistanol trisulfate, inhibits pp60v-src protein tyrosine kinase activity.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Ascosalipyrrolidinone A, an antimicrobial alkaloid, from the obligate marine fungus Ascochyta salicorniae

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Regulation and inhibition of phospholipase A2.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Mammalian secreted phospholipases A2 and their pathophysiological significance in inflammatory diseases

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Petrosaspongiolides M−R: New Potent and Selective Phospholipase A2Inhibitors from the New Caledonian Marine SpongePetrosaspongianigra

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Phospholipase A2 Inhibitors from Marine Organisms

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Novel molecules that interact with microtubules and have functional activity similar to Taxol

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

The cyanobacterial origin of potent anticancer agents originally isolated from sea hares.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

DNA: still a target worth aiming at? A review of new DNA-interactive agents

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Antitumor compounds from tunicates

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Antitumor activity and biochemical effects of topsentin

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Enantioselective Total Synthesis of Ecteinascidin 743

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Antitumor activity- and gene expression-based profiling of ecteinascidin Et 743 and phthalascidin Pt 650.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp.(1)

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Contignasterol, a highly oxygenated steroid with the unnatural 14.beta. configuration from the marine sponge Petrosia contignata Thiele, 1899

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Amino acid derivatives from the marine sponge Jaspis digonoxea

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Functional versus chemical diversity: is biodiversity important for drug discovery?

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

Chemical diversity: a function of biodiversity

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021

A natural edge: nature still offers the greatest drug diversity

1 reference

https://api.crossref.org/works/10.1016/S1359-6446(03)02713-2

7 January 2021