Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides (Q28145802)

Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

Europe PubMed Central

title

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides (English)

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author name string

N G Seidah

series ordinal

1

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M Chrétien

series ordinal

2

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language of work or name

English

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publication date

27 November 1999

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published in

Brain Research

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volume

848

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issue

1-2

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page(s)

45-62

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cites work

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Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library

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The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates

7 January 2021

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Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity

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PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

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7B2 is a specific intracellular binding protein of the prohormone convertase PC2

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Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

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Substrate phosphorylation can inhibit proteolysis by trypsin-like enzymes

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A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites

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Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin

7 January 2021

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7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway

7 January 2021

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Isolation and primary structure of novel neurointermediate pituitary peptides derived from the C-terminal of the rat vasopressin-neurophysin precursor (propressophysin).

7 January 2021

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Isolation, purification, and characterization of gamma-lipotropic hormone from sheep pituitary glands

7 January 2021

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Inhibition of Soluble Recombinant Furin by Human Proteinase Inhibitor 8

7 January 2021

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Region specific expression of furin mRNA in the rat brain

7 January 2021

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Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4( ) cell lines

7 January 2021

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Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary

7 January 2021

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Cellular localization of the prohormone convertases in the hypothalamic paraventricular and supraoptic nuclei: selective regulation of PC1 in corticotrophin-releasing hormone parvocellular neurons mediated by glucocorticoids

7 January 2021

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Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.

7 January 2021

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Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

7 January 2021

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Expression of neuropeptide processing enzymes and neurosecretory proteins in ependyma and choroid plexus epithelium

7 January 2021

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Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

7 January 2021

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A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4

7 January 2021

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Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

7 January 2021

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Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.

7 January 2021

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Proparathyroid Hormone Is Preferentially Cleaved to Parathyroid Hormone by the Prohormone Convertase Furin

7 January 2021

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Molecular cloning and characterization of cDNA sequences coding for rat relaxin

7 January 2021

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

7 January 2021

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An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor

7 January 2021

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Fluorescent Peptidyl Substrates as an Aid in Studying the Substrate Specificity of Human Prohormone Convertase PC1 and Human Furin and Designing a Potent Irreversible Inhibitor

7 January 2021

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alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

7 January 2021

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Proprotein-processing endoprotease furin decreases regulated secretory pathway-specific proteins in the pancreatic beta cell line MIN6.

7 January 2021

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Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

7 January 2021

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Proprotein-processing endoprotease furin controls the growth and differentiation of gastric surface mucous cells

7 January 2021

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Cloning and sequence of cDNA coding for alpha 1-antitrypsin

7 January 2021

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Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity

7 January 2021

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Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations

7 January 2021

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Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells

7 January 2021

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Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin

7 January 2021

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Nerve growth factor and proprotein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: their presence in Schwann cells, macrophages, and smooth muscle cells

7 January 2021

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Impaired fertility in mice deficient for the testicular germ-cell protease PC4

7 January 2021

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A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus

7 January 2021

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Mechanism of the Facilitation of PC2 Maturation by 7B2: Involvement in ProPC2 Transport and Activation but Not Folding

7 January 2021

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In vitro characterization of the novel proprotein convertase PC7.

7 January 2021

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Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1

7 January 2021

1 reference

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Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0006-8993(99)01909-5

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

7 January 2021

1 reference

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Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function

7 January 2021

1 reference

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Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder

7 January 2021

1 reference

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Activation of the Kexin from Schizosaccharomyces pombe Requires Internal Cleavage of Its Initially Cleaved Prosequence

7 January 2021

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Peptides derived by processing of rat prosomatostatin near the amino-terminus: characterization, tissue distribution, and release

7 January 2021

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Regulation of PACE propeptide-processing activity: requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation

7 January 2021

1 reference

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Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases

7 January 2021

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Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases.

7 January 2021

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Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

7 January 2021

1 reference

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Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis

7 January 2021

1 reference

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The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0006-8993(99)01909-5

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

7 January 2021

1 reference

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Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

7 January 2021

1 reference

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Eukaryotic protein processing: endoproteolysis of precursor proteins

7 January 2021

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The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions

7 January 2021

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The family of pro-hormone and pro-protein convertases

7 January 2021

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Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins

7 January 2021

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cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0006-8993(99)01909-5

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

7 January 2021

1 reference

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Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily

7 January 2021

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Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

7 January 2021

1 reference

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Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

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Translating cell biology into therapeutic advances in Alzheimer's disease

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Subtilases: the superfamily of subtilisin-like serine proteases

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Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3

7 January 2021

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Insulin biosynthesis: evidence for a precursor

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Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment

7 January 2021

1 reference

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Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered α2-macroglobulin containing a furin recognition sequence in the bait region

7 January 2021

1 reference

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Immunohistochemical distribution of the prohormone convertase PC5-A in rat brain

7 January 2021

1 reference

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The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease

7 January 2021

1 reference

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Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments

7 January 2021

1 reference

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The developmental expression in the rat CNS and peripheral tissues of proteases PC5 and PACE4 mRNAs: comparison with other proprotein processing enzymes.

7 January 2021

1 reference

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The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity.

7 January 2021

1 reference

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Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0006-8993(99)01909-5

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

7 January 2021

1 reference

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Structural Elements That Direct Specific Processing of Different Mammalian Subtilisin-like Prohormone Convertases

7 January 2021

1 reference

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Proteolytic processing in the secretory pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0006-8993(99)01909-5

Structural elements of PC2 required for interaction with its helper protein 7B2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0006-8993(99)01909-5

Intramolecular Chaperone: The Role of the Pro-Peptide in Protein Folding

7 January 2021

1 reference

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10.1016/S0006-8993(99)01909-5

7 January 2021

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

10701998

1 reference

Consolidated OpenCitations Corpus – April 2017