Characterization of S6K2, a novel kinase homologous to S6K1 (Q28144592)

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C J Kuo

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J Lippincott

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N Terada

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J Blenis

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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language of work or name

English

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publication date

9 September 1999

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published in

Oncogene

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volume

18

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issue

36

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page(s)

5108-14

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cites work

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

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Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin

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The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

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The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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Differential subcellular localisation of two isoforms of p70 S6 protein kinase.

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Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

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Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

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Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

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Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

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Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

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Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

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Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

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Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

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Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

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Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

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Phosphorylation and activation of p70s6k by PDK1

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p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

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Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells

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Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

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Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

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Nerve and epidermal growth factor induce protein synthesis and eIF2B activation in PC12 cells

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inferred from DOI database lookup

7 January 2021

based on heuristic

Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt

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inferred from DOI database lookup

7 January 2021

based on heuristic

Nuclear localization of p85s6k: functional requirement for entry into S phase.

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