FAK integrates growth-factor and integrin signals to promote cell migration (Q28144169)

2

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D Ilic

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C K Klingbeil

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E Schaefer

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C H Damsky

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D D Schlaepfer

alpha vbeta 3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF

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language of work or name

English

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publication date

May 2000

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published in

Nature Cell Biology

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volume

2

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issue

5

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page(s)

249-56

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cites work

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7 January 2021

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

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7 January 2021

Integrin signaling and cell growth control

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7 January 2021

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7 January 2021

Interactions between mitogenic stimuli, or, a thousand and one connections

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7 January 2021

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions

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7 January 2021

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK

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7 January 2021

Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses

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7 January 2021

Interaction of focal adhesion kinase with cytoskeletal protein talin

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7 January 2021

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

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7 January 2021

Signaling through focal adhesion kinase

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7 January 2021

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

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7 January 2021

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

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7 January 2021

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

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7 January 2021

Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

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7 January 2021

Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

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7 January 2021

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation

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7 January 2021

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

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7 January 2021

The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor

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7 January 2021

Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells

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7 January 2021

Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

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7 January 2021

Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

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7 January 2021

Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility

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7 January 2021

Focal adhesion kinase promotes phospholipase C-gamma1 activity.

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7 January 2021

Association of focal adhesion kinase with Grb7 and its role in cell migration

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7 January 2021

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

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7 January 2021

The N-termini of FAK and JAKs contain divergent band 4.1 domains

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7 January 2021

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein

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7 January 2021

A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.

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7 January 2021

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

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7 January 2021

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

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7 January 2021

A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer

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7 January 2021

Focal adhesion kinase and its potential involvement in tumor invasion and metastasis

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7 January 2021

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

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7 January 2021

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

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7 January 2021