Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation (Q28143624)

2

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George S. Robertson

3

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John P. Vaillancourt

4

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Yanxia Zhu

5

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JingQi Huang

6

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Andréa LeBlanc

7

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David Smith

8

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Michael Rigby

9

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Mark S. Shearman

10

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Earl E. Clarke

11

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Hui Zheng

12

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Leonardus H.T. Van Der Ploeg

13

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Salvatore C. Ruffolo

14

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Nancy A. Thornberry

15

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Steve Xanthoudakis

16

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Robert J. Zamboni

17

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Sophie Roy

18

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Donald W. Nicholson

Human ICE/CED-3 protease nomenclature

19

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language of work or name

English

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publication date

30 April 1999

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April 1999

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published in

Cell

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volume

97

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issue

3

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page(s)

395-406

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cites work

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Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons.

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Co-localization of the cysteine protease caspase-3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat

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The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

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Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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Generation of amyloid β protein from its precursor is sequence specific

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Mechanisms of neuronal death in Alzheimer's disease

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Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments.

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Inhibition of human caspases by peptide-based and macromolecular inhibitors

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Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

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Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

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Amyloid precursor protein metabolism in primary cell cultures of neurons, astrocytes, and microglia

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Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients

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Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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An induced proximity model for caspase-8 activation.

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Caspases: killer proteases

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation

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Temporal profile of neuronal damage in a model of transient forebrain ischemia

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

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The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

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Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein

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The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

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Role of the beta-amyloid protein in Alzheimer's disease.

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Evidence for apoptotic cell death in Alzheimer's disease.

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

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Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

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Autoproteolytic activation of pro-caspases by oligomerization

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Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells

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