MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines (Q28142772)

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object named as

C Caldas

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author name string

D G Huntsman

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M Muleris

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S J Batley

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V P Collins

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L M Wiedemann

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S Aparicio

Establishment and characterization of a megakaryoblast cell line with amplification of MLL.

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language of work or name

English

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publication date

23 December 1999

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published in

Oncogene

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volume

18

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issue

56

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page(s)

7975-84

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cites work

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Involvement of the ALL-1 gene in a solid tumor

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FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands

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Trithorax is required to maintain engrailed expression in a subset of engrailed-expressing cells

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Isolation and characterization of a pufferfish MLL (mixed lineage leukemia)-like gene (fMll) reveals evolutionary conservation in vertebrate genes related to Drosophila trithorax

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

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A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors

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Association of SET domain and myotubularin-related proteins modulates growth control

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A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

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Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product

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Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas

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MLL2: A new mammalian member of the trx/MLL family of genes

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Functions of mammalian Polycomb group and trithorax group related genes

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Targets of homeotic gene control in Drosophila.

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases

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Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;11).

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A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

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Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro

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MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)

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Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia

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ALL-1 partial duplication in acute leukemia

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EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

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Altered Hox expression and segmental identity in Mll-mutant mice

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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

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Amplification of DNA sequences from chromosome 19q13.1 in human pancreatic cell lines

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Mapping of 18 probes on human chromosome 18 using single- and double-color FISH

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Molecular cytogenetics of primary breast cancer by CGH

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Analysis of the region of the 5' end of the MLL gene involved in genomic duplication events.

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7 January 2021