Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain (Q28142613)

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C Wang

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E Spencer

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L Yang

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A Braun

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J You

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C Slaughter

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C Pickart

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Z J Chen

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor

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language of work or name

English

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publication date

13 October 2000

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published in

Cell

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volume

103

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issue

2

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page(s)

351-61

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cites work

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

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Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

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TRAF6 is a signal transducer for interleukin-1

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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

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Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

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Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

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The IKK complex: an integrator of all signals that activate NF-kappaB?

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Substrate targeting in the ubiquitin system

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Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

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MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways

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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

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Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

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Identification and characterization of an IkappaB kinase

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CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter

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Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.

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The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

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Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

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Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

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A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

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Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

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Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.

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p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins

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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

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Construct for high-level expression and low misincorporation of lysine for arginine during expression of pET-encoded eukaryotic proteins in Escherichia coli

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Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

11057907

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Consolidated OpenCitations Corpus – April 2017