The biology of Stat4 and Stat6 (Q28138102)

Functional diversity of helper T lymphocytes

Europe PubMed Central

title

The biology of Stat4 and Stat6 (English)

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author name string

A L Wurster

series ordinal

1

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T Tanaka

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2

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M J Grusby

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3

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language of work or name

English

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publication date

15 May 2000

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published in

Oncogene

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volume

19

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issue

21

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page(s)

2577-84

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cites work

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7 January 2021

Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

1 reference

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7 January 2021

Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice

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7 January 2021

cDNA cloning and characterization of the human interleukin 13 receptor alpha chain

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7 January 2021

Checkpoints in the progression of autoimmune disease: lessons from diabetes models

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7 January 2021

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4( ) versus CD8( ) T cells

1 reference

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7 January 2021

Products from mast cells influence T lymphocyte proliferation and cytokine production—relevant to allergic asthma?

1 reference

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7 January 2021

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

1 reference

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7 January 2021

T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.

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7 January 2021

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

1 reference

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7 January 2021

Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

A new protein containing an SH2 domain that inhibits JAK kinases

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Defective STAT signaling by the leptin receptor in diabetic mice

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

STATs as Mediators of Cytokine-Induced Responses

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

An interleukin-4-induced transcription factor: IL-4 Stat

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Functional subsets of allergen-reactive human CD4 T cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Human interleukin-13 activates the interleukin-4-dependent transcription factor NF-IL4 sharing a DNA binding motif with an interferon-gamma-induced nuclear binding factor

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Allergy-associated I epsilon and Ec epsilon receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Generation and analysis of interleukin-4 deficient mice

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Jaks and STATs: biological implications

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: a cellular signal for hypertrophy in cardiac muscle

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Requirements for interleukin-4-induced gene expression and functional characterization of Stat6

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Mutational analysis of the STAT6 SH2 domain

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Structure and function of a new STAT-induced STAT inhibitor

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

The IL-4 receptor: signaling mechanisms and biologic functions

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

An interleukin 4 (IL-4)-independent pathway for CD4 T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Cytokines induce the development of functionally heterogeneous T helper cell subsets

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Stat6 and Jak1 are common elements in platelet-derived growth factor and interleukin-4 signal transduction pathways in NIH 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Components of a Stat recognition code: evidence for two layers of molecular selectivity

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

A family of cytokine-inducible inhibitors of signalling

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Essential role of Stat6 in IL-4 signalling

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Structure of the amino-terminal protein interaction domain of STAT-4

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Stat3 and Stat4: members of the family of signal transducers and activators of transcription

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021

The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203485

7 January 2021