BH3-only proteins: a 20-year stock-take (Q28085220)

language of work or name

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March 2015

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282

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PubMed

issue

6

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PubMed

page(s)

1006-16

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

PubMed

cites work

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Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

21 January 2018

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

21 January 2018

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Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway.

21 January 2018

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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

21 January 2018

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Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis

21 January 2018

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Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm.

21 January 2018

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MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains

21 January 2018

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Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis

21 January 2018

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BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner

21 January 2018

1 reference

Tissue transglutaminase is a multifunctional BH3-only protein

21 January 2018

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

21 January 2018

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Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death

21 January 2018

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The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells

21 January 2018

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Caspase cleavage of HER-2 releases a Bad-like cell death effector

21 January 2018

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Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

21 January 2018

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The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

21 January 2018

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Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor

21 January 2018

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Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus

21 January 2018

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Bcl-2-family proteins: the role of the BH3 domain in apoptosis

21 January 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

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The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

21 January 2018

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Bax directly induces release of cytochrome c from isolated mitochondria

21 January 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

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Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

21 January 2018

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Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

21 January 2018

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Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

21 January 2018

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

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Structural insights into the degradation of Mcl-1 induced by BH3 domains

21 January 2018

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BID: a novel BH3 domain-only death agonist

21 January 2018

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

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p53 regulates a non-apoptotic death induced by ROS.

21 January 2018

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Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

21 January 2018

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BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest

21 January 2018

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Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival

21 January 2018

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Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.

21 January 2018

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

21 January 2018

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Dual role of proapoptotic BAD in insulin secretion and beta cell survival

21 January 2018

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A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators

21 January 2018

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Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity.

21 January 2018

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Bid mediates anti-apoptotic COX-2 induction through the IKKbeta/NFkappaB pathway due to 5-MCDE exposure

21 January 2018

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Proapoptotic BID is an ATM effector in the DNA-damage response

21 January 2018

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Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress

21 January 2018

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The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

21 January 2018

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Bid plays a role in the DNA damage response.

21 January 2018

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Non-apoptotic role of BID in inflammation and innate immunity

21 January 2018

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ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

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Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

21 January 2018

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BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.

21 January 2018

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Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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Potential roles of antisense oligonucleotides in cancer therapy. The example of Bcl-2 antisense oligonucleotides

21 January 2018

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Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma

21 January 2018

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BH3 mimetics: status of the field and new developments

21 January 2018

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Expression of the apoptosis inhibitor Bcl-2 in sputum eosinophils from children with acute asthma

21 January 2018

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The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death

21 January 2018

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CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)-mediated apoptosis

21 January 2018

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

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BH3-only proteins in apoptosis at a glance

21 January 2018

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Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.

21 January 2018

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Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis.

21 January 2018

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Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice

21 January 2018

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Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections

21 January 2018

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CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress

21 January 2018

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The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

21 January 2018

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