Indoxyl Sulfate-Review of Toxicity and Therapeutic Strategies (Q28075033)

main subject

heterocyclic compound

1 reference

17 September 2019

Sheldon Leong

1

1 reference

Tammy Sirich

series ordinal

2

1 reference

language of work or name

1 reference

30 November 2016

2 references

17 September 2019

2 references

17 September 2019

8

1 reference

issue

12

1 reference

Creative Commons Attribution

copyright license

1 reference

17 September 2019

0 references

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

A Randomized, Controlled Trial of Oral Intestinal Sorbent AST-120 on Renal Function Deterioration in Patients with Advanced Renal Dysfunction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Protein-Bound Uremic Toxin Profiling as a Tool to Optimize Hemodialysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Indoxyl sulfate, not p-cresyl sulfate, is associated with cognitive impairment in early-stage chronic kidney disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY): A Randomized Trial.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

The Influence of Dietary Protein Intake on Mammalian Tryptophan and Phenolic Metabolites.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Probiotics and chronic kidney disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

The Role of Liver in Determining Serum Colon-Derived Uremic Solutes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Free Levels of Selected Organic Solutes and Cardiovascular Morbidity and Mortality in Hemodialysis Patients: Results from the Retained Organic Solutes and Clinical Outcomes (ROSCO) Investigators

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Association of indoxyl sulfate with heart failure among patients on hemodialysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Prominent accumulation in hemodialysis patients of solutes normally cleared by tubular secretion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Retained organic solutes, patient characteristics and all-cause and cardiovascular mortality in hemodialysis: results from the retained organic solutes and clinical outcomes (ROSCO) investigators

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Removal of protein-bound uraemic toxins by haemodialysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Numerous protein-bound solutes are cleared by the kidney with high efficiency

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Uremic serum and solutes increase post-vascular interventional thrombotic risk through altered stability of smooth muscle cell tissue factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Influence of serum in hemodialysis patients on the expression of intestinal and hepatic transporters for the excretion of pravastatin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

The production of p-cresol sulfate and indoxyl sulfate in vegetarians versus omnivores

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Selectively increasing the clearance of protein-bound uremic solutes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Colonic contribution to uremic solutes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Indoxyl Sulfate Is a Nephro-Vascular Toxin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Effects of renal failure on drug transport and metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Digestive processes in the human colon.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Assessments of clinical trials of charcoal hemoperfusion in uremic patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Quantitative indices of clinical uremia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Bioengineered kidney tubules efficiently excrete uremic toxins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Indoxyl sulfate and progression of renal failure: effects of a low-protein diet and oral sorbent on indoxyl sulfate production in uremic rats and undialyzed uremic patients

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Contributions of hippurate, indoxyl sulfate, and o-hydroxyhippurate to impaired ligand binding by plasma in azotemic humans

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Assessment of urea and other uremic markers for quantification of dialysis efficacy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

Intradialytic removal of protein-bound uraemic toxins: role of solute characteristics and of dialyser membrane

2 June 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Removal of P-cresol sulfate by hemodialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Effect of increasing dialyzer mass transfer area coefficient and dialysate flow on clearance of protein-bound solutes: a pilot crossover trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Serum free indoxyl sulfate associated with in-stent restenosis after coronary artery stentings.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Serum protein-bound uraemic toxins and clinical outcomes in haemodialysis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Metabolic Profiling of Impaired Cognitive Function in Patients Receiving Dialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Indoxyl Sulfate Induces Epithelial-to-Mesenchymal Transition in Rat Kidneys and Human Proximal Tubular Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Indoxyl sulfate exacerbates low bone turnover induced by parathyroidectomy in young adult rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Prospective evaluation of the change of predialysis protein-bound uremic solute concentration with postdilution online hemodiafiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Increasing the clearance of protein-bound solutes by addition of a sorbent to the dialysate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Mixed matrix hollow fiber membranes for removal of protein-bound toxins from human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Very low protein diet reduces indoxyl sulfate levels in chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Dietary protein and fiber in end stage renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Bifidobacterium in gastro-resistant seamless capsule reduces serum levels of indoxyl sulfate in patients on hemodialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Effects of AST-120 on Blood Concentrations of Protein-Bound Uremic Toxins and Biomarkers of Cardiovascular Risk in Chronic Dialysis Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8120358

Levels of indoxyl sulfate are associated with severity of coronary atherosclerosis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5198552

A method for the determination of urinary indoxyl sulphate (Indican)

27 November 2018

1 reference

12 December 2020

A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study of AST-120 (Kremezin) in patients with moderate to severe CKD

1 reference

12 December 2020

Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis

1 reference

12 December 2020

Indoxyl sulfate stimulates renal synthesis of transforming growth factor-beta 1 and progression of renal failure

1 reference

12 December 2020

Studies on the pathogenesis of uremia comparatie determinaions of glucuronic acid, indican, free and bound phenols in the serum, cerebrospinal fluid, and urine of renal diseases with and without uremia

1 reference

12 December 2020

Effect of a sustained difference in hemodialytic clearance on the plasma levels of p-cresol sulfate and indoxyl sulfate

1 reference

12 December 2020

Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis

1 reference

12 December 2020

Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate

1 reference

12 December 2020

Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography

1 reference

12 December 2020

Serum indican and urinary indican excretion in achlorhydria

1 reference

12 December 2020

A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step

1 reference

12 December 2020

SERUM INDICAN IN RENAL DISEASE

1 reference

12 December 2020

[RESEARCH ON EXTRARENAL PURIFICATION WITH THE AID OF ACTIVATED CHARCOAL]

1 reference

12 December 2020

Indoxyl sulfate increases the gene expressions of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys

1 reference

12 December 2020

The search for the uremic toxin(s)

1 reference

12 December 2020

Oral sorbent suppresses accumulation of albumin-bound indoxyl sulphate in serum of haemodialysis patients

1 reference

12 December 2020

The National Kidney Foundation K/DOQI clinical practice guidelines for dietary protein intake for chronic dialysis patients

1 reference

12 December 2020

Decreased drug binding in uraemia: effect of indoxyl sulphate and other endogenous substances on the binding of drugs and dyes to human albumin

1 reference

12 December 2020

Identifiers

DOI

10.3390/TOXINS8120358

0 references

PMC publication ID

5198552

0 references

PubMed publication ID

27916890

1 reference