DNA Polymerase θ: A Unique Multifunctional End-Joining Machine (Q28073133)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

review article

1 reference

title

DNA Polymerase θ: A Unique Multifunctional End-Joining Machine (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

Tatiana Kent

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

author name string

Ekaterina Kashkina

series ordinal

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

Richard T Pomerantz

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

language of work or name

1 reference

21 September 2016

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

volume

7

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

issue

9

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

23 March 2020

page(s)

67

0 references

copyright license

start time

21 September 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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20 March 2017

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Structure of the DNA Repair Helicase Hel308 Reveals DNA Binding and Autoinhibitory Domains

20 March 2017

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RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

20 March 2017

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Structural basis for DNA duplex separation by a superfamily-2 helicase

20 March 2017

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Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands

20 March 2017

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

20 March 2017

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20 March 2017

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The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

20 March 2017

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Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways

20 March 2017

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Crystal structure of Thermus aquaticus DNA polymerase

20 March 2017

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

20 March 2017

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

20 March 2017

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Regulation of DNA double-strand break repair pathway choice

20 March 2017

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IgH class switching and translocations use a robust non-classical end-joining pathway

20 March 2017

1 reference

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DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

20 March 2017

1 reference

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Mechanism of suppression of chromosomal instability by DNA polymerase POLQ

20 March 2017

1 reference

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Role of mammalian Mre11 in classical and alternative nonhomologous end joining

20 March 2017

1 reference

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The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm

20 March 2017

1 reference

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Phenotype-based identification of mouse chromosome instability mutants

20 March 2017

1 reference

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Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

20 March 2017

1 reference

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PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

7 April 2017

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Structure and mechanism of helicases and nucleic acid translocases

7 April 2017

1 reference

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DNA helicase Srs2 disrupts the Rad51 presynaptic filament

7 April 2017

1 reference

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RecQ helicases: caretakers of the genome

7 April 2017

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DNA polymerases: structural diversity and common mechanisms

7 April 2017

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Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

7 April 2017

1 reference

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Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

29 September 2017

1 reference

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A role for human homologous recombination factors in suppressing microhomology-mediated end joining

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Mechanism and regulation of DNA end resection in eukaryotes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Human DNA polymerase α in binary complex with a DNA:DNA template-primer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

A mechanism for the suppression of homologous recombination in G1 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Structural mechanisms of DNA binding and unwinding in bacterial RecQ helicases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

A role for DNA polymerase θ in the timing of DNA replication.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Physical interaction between archaeal DNA repair helicase Hel308 and Replication Protein A (RPA).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Non-hexameric DNA helicases and translocases: mechanisms and regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Regulation of DNA repair throughout the cell cycle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Novel pro- and anti-recombination activities of the Bloom's syndrome helicase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

New mammalian cellular systems to study mutations introduced at the break site by non-homologous end-joining

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Site-directed mutagenesis of motif III in PcrA helicase reveals a role in coupling ATP hydrolysis to strand separation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Double-strand break repair in Ku86- and XRCC4-deficient cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Enzymic Unwinding of DNA. 2. Chain Separation by an ATP-Dependent DNA Unwinding Enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Characterization of the mus308 gene in Drosophila melanogaster

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

mus308 mutants of Drosophila exhibit hypersensitivity to DNA cross-linking agents and are defective in a deoxyribonuclease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5042397

Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways.

2 June 2018

1 reference

https://api.crossref.org/works/10.3390/GENES7090067

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/GENES7090067

DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/GENES7090067

Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/GENES7090067

Rag mutations reveal robust alternative end joining

21 January 2018

2 references

https://api.crossref.org/works/10.3390/GENES7090067

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/27657134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27657134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/GENES7090067

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27657134 AND SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

27657134

2 references