Targeting Mechanotransduction at the Transcriptional Level: YAP and BRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis (Q28070012)

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Aibar Temirbekuly

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1 reference

Kuralay Kongrtay

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1 reference

Leah C. Wanshura

4

1 reference

Jeannette Kunz

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language of work or name

1 reference

1 December 2016

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Frontiers in Pharmacology

published in

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volume

7

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page(s)

462

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αv integrins: key regulators of tissue fibrosis

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The Hippo Signaling Pathway in Development and Cancer

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The mechanisms behind the therapeutic activity of BET bromodomain inhibition

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Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response

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Involvement of integrin-linked kinase in carbon tetrachloride-induced hepatic fibrosis in rats

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Role of YAP/TAZ in mechanotransduction

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Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

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Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis

29 September 2017

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HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension.

29 September 2017

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29 September 2017

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Integrin signalling regulates YAP and TAZ to control skin homeostasis

29 September 2017

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YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis.

29 September 2017

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Focal Adhesion Kinase Regulates Fibroblast Migration via Integrin beta-1 and Plays a Central Role in Fibrosis

29 September 2017

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BRD4 is a novel therapeutic target for liver fibrosis

29 September 2017

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Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis

29 September 2017

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Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway

29 September 2017

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Beating the odds: BETs in disease

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The αvβ1 integrin plays a critical in vivo role in tissue fibrosis

29 September 2017

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Novel insights into the function and dynamics of extracellular matrix in liver fibrosis

29 September 2017

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Collagen matrix as a tool in studying fibroblastic cell behavior

29 September 2017

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Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

29 September 2017

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Origin of myofibroblasts in the fibrotic liver in mice

29 September 2017

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Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

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Bile acids activate YAP to promote liver carcinogenesis

29 September 2017

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Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology.

29 September 2017

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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

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2 June 2018

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BET bromodomain is a novel regulator of TAZ and its activity

21 January 2018

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Antifibrotic effects of focal adhesion kinase inhibitor in bleomycin-induced pulmonary fibrosis in mice

21 January 2018

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The Hippo pathway effector YAP controls mouse hepatic stellate cell activation.

21 January 2018

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Fibrosis--a common pathway to organ injury and failure

21 January 2018

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The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

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Fibrosis--A Common Pathway to Organ Injury and Failure

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27990121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FPHAR.2016.00462

0 references

1 reference

PubMed publication ID

27990121

1 reference