N-methyl-2-pyridone-5-carboxamide (2PY)-Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin (Q28069862)

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15 November 2016

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17 September 2019

29 May 2020

17 January 2024

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17 September 2019

17 January 2024

8

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issue

11

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Creative Commons Attribution

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339

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17 September 2019

29 May 2020

17 January 2024

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

1 reference

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20 March 2017

1 reference

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

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Protein-bound toxins: has the Cinderella of uraemic toxins turned into a princess?

24 May 2017

1 reference

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Efficacy and safety of nicotinamide in haemodialysis patients: the NICOREN study

29 September 2017

1 reference

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A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

29 September 2017

1 reference

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Meta-Analysis of the Associations of p-Cresyl Sulfate (PCS) and Indoxyl Sulfate (IS) with Cardiovascular Events and All-Cause Mortality in Patients with Chronic Renal Failure

29 September 2017

1 reference

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Rationale and Approaches to Phosphate and Fibroblast Growth Factor 23 Reduction in CKD.

29 September 2017

1 reference

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Use of nicotinamide to treat hyperphosphatemia in dialysis patients

29 September 2017

1 reference

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p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

29 September 2017

1 reference

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Normal and pathologic concentrations of uremic toxins

29 September 2017

1 reference

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Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition

29 September 2017

1 reference

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Cellular toxicity of nicotinamide metabolites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127135

4-Pyridone-3-carboxamide-1-β-D-ribonucleoside triphosphate (4PyTP), a novel NAD metabolite accumulating in erythrocytes of uremic children: a biomarker for a toxic NAD analogue in other tissues?

29 September 2017

1 reference

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Niacin and its metabolites: role of LC‐MS/MS bioanalytical methods and update on clinical pharmacology. An overview

29 September 2017

1 reference

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Simultaneous determination of niacin and its metabolites—nicotinamide, nicotinuric acid and N‐methyl‐2‐pyridone‐5‐carboxamide—in human plasma by LC‐MS/MS and its application to a human pharmacokinetic study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127135

What is new in uremic toxicity?

29 September 2017

1 reference

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Chronic kidney disease as cause of cardiovascular morbidity and mortality

29 September 2017

1 reference

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N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127135

Review on uremic toxins: classification, concentration, and interindividual variability

29 September 2017

1 reference

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Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat

29 September 2017

1 reference

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Nicotinic acid-induced toxicity associated with cytopenia and decreased levels of thyroxine-binding globulin

29 September 2017

1 reference

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Niacin versus niacinamide

29 September 2017

1 reference

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Nicotinamide inhibits sodium-dependent phosphate cotransport activity in rat small intestine

2 June 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodium-dependent phosphate transporter in rats with adenine-induced renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

Niacin status, NAD distribution and ADP-ribose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

Nicotinamide metabolites accumulate in the tissues of uremic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

Thrombocytopenia induced by nicotinamide in hemodialysis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/TOXINS8110339

Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation

21 January 2018

1 reference

12 December 2020

High-performance liquid chromatographic determination of nicotinamide and its metabolites in human and murine plasma and urine

1 reference

12 December 2020

ISOLATION OF N-METHYL-2-PYRIDONE-5-CARBOXAMIDE FROM HEMODIALYSIS FLUID OBTAINED FROM UREMIC PATIENTS

1 reference

12 December 2020

N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K)

1 reference

12 December 2020

Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure

1 reference

12 December 2020

Pharmacological doses of nicotinic acid and nicotinamide are independently metabolized in rats

1 reference

12 December 2020

N'-METHYL-2-PYRIDONE-5-CARBOXAMIDE INHUMAN PLASMA

1 reference

12 December 2020

Determination of niacin metabolites 1-methyl-5-carboxylamide-2-pyridone and n-1-methylnicotinamide in urine by high-performance liquid chromatography

1 reference

12 December 2020

Renal tubular elimination of N1-methylnicotinamide

1 reference

12 December 2020

Simultaneous micro-determination of nicotinamide and its major metabolites, N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-3-carboxamide, by high-performance liquid chromatography

1 reference

12 December 2020

Identifiers

DOI

10.3390/TOXINS8110339

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1 reference

PubMed publication ID

27854278

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