Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies (Q28068448)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

review article

1 reference

title

Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

0 references

3

1 reference

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26 March 2020

author name string

Xiaohong Ruby Xu

1

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

Naadiya Carrim

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

Thomas McKeown

4

2 references

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26 March 2020

Rodrigo Matos Pinto Coelho

6

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

Xi Lei

7

2 references

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26 March 2020

Pingguo Chen

8

2 references

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26 March 2020

Jianhua Xu

9

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

Xiangrong Dai

10

2 references

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26 March 2020

Benjamin Xiaoyi Li

11

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

Heyu Ni

12

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

Tyler W Stratton

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

language of work or name

1 reference

4 October 2016

2 references

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26 March 2020

2 references

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26 March 2020

volume

14

2 references

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26 March 2020

issue

Suppl 1

2 references

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26 March 2020

page(s)

29

2 references

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A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation

26 March 2020

cites work

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Targeting glycoprotein VI and the immunoreceptor tyrosine-based activation motif signaling pathway

20 March 2017

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Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke

20 March 2017

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Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet

20 March 2017

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A novel adaptation of the integrin PSI domain revealed from its crystal structure

20 March 2017

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Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation

20 March 2017

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Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha

20 March 2017

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Integrins: bidirectional, allosteric signaling machines

20 March 2017

1 reference

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A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

20 March 2017

1 reference

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Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain

20 March 2017

1 reference

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A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion

20 March 2017

1 reference

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Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

20 March 2017

1 reference

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Increased thrombogenesis and embolus formation in mice lacking glycoprotein V

20 March 2017

1 reference

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Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

20 March 2017

1 reference

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Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke

20 March 2017

1 reference

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Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

29 September 2017

1 reference

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Platelets, immune-mediated thrombocytopenias, and fetal hemorrhage

29 September 2017

1 reference

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Fibronectin maintains the balance between hemostasis and thrombosis

29 September 2017

1 reference

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Thrombotic microangiopathy: Caplacizumab accelerates resolution of acute acquired TTP.

29 September 2017

1 reference

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Glucagon-Like Peptide 1 Receptor Activation Attenuates Platelet Aggregation and Thrombosis.

29 September 2017

1 reference

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Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury

29 September 2017

1 reference

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Extracellular matrix proteins in the regulation of thrombus formation.

29 September 2017

1 reference

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Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura

29 September 2017

1 reference

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Podoplanin-positive periarteriolar stromal cells promote megakaryocyte growth and proplatelet formation in mice by CLEC-2.

29 September 2017

1 reference

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Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association

29 September 2017

1 reference

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Essential Roles of Toll-Like Receptors in Atherosclerosis

29 September 2017

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Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis.

29 September 2017

1 reference

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Fibrin activates GPVI in human and mouse platelets

29 September 2017

1 reference

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Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice.

29 September 2017

1 reference

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Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

29 September 2017

1 reference

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Antiplatelet drugs: which targets for which treatments?

29 September 2017

1 reference

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αIIbβ3: structure and function

29 September 2017

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Platelets at the interface of thrombosis, inflammation, and cancer.

29 September 2017

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A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury

29 September 2017

1 reference

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Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage

29 September 2017

1 reference

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Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: haemostasis, platelet activation and antithrombotic therapy

29 September 2017

1 reference

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Critical role of platelet glycoprotein ibα in arterial remodeling

29 September 2017

1 reference

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Novel antiplatelet agents in acute coronary syndrome

29 September 2017

1 reference

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Plasma fibronectin supports hemostasis and regulates thrombosis

29 September 2017

1 reference

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RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction

29 September 2017

1 reference

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Platelets guide the formation of early metastatic niches

29 September 2017

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Platelet membrane glycoproteins: a historical review

29 September 2017

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Management of thrombotic thrombocytopenic purpura: current perspectives

29 September 2017

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Thrombosis: tangled up in NETs

29 September 2017

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Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin

29 September 2017

1 reference

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The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in stroke

29 September 2017

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Identification of α2β1 integrin inhibitor VP-i with anti-platelet properties in the venom of Vipera palaestinae.

29 September 2017

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Novel antiplatelet agents: ALX-0081, a Nanobody directed towards von Willebrand factor

29 September 2017

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The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination

29 September 2017

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Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries

29 September 2017

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Inhibitors of the interaction between von Willebrand factor and platelet GPIb/IX/V.

29 September 2017

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Platelet GPVI: a target for antithrombotic therapy?!

29 September 2017

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Vorapaxar in the secondary prevention of atherothrombotic events

29 September 2017

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Advances in Antiplatelet Therapy

29 September 2017

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Arterial thrombosis—insidious, unpredictable and deadly

29 September 2017

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The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies

29 September 2017

1 reference

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Anti‐platelet therapy: glycoprotein IIb‐IIIa antagonists

29 September 2017

1 reference

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Ischaemic stroke: a thrombo‐inflammatory disease?

29 September 2017

1 reference

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Novel Antiplatelet Drug Revacept (Dimeric Glycoprotein VI-Fc) Specifically and Efficiently Inhibited Collagen-Induced Platelet Aggregation Without Affecting General Hemostasis in Humans

29 September 2017

1 reference

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Platelets and the immune continuum

29 September 2017

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Combating innate inflammation: a new paradigm for acute treatment of stroke?

29 September 2017

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Antiplatelet therapies for the treatment of cardiovascular disease

29 September 2017

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Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro

29 September 2017

1 reference

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Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism

29 September 2017

1 reference

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Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor

29 September 2017

1 reference

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The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons.

29 September 2017

1 reference

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Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

29 September 2017

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Triggers, targets and treatments for thrombosis

29 September 2017

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Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis

29 September 2017

1 reference

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Cell adhesion mechanisms in platelets

29 September 2017

1 reference

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Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released

29 September 2017

1 reference

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Platelets, inflammation and atherosclerosis

29 September 2017

1 reference

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Adhesion mechanisms in platelet function

29 September 2017

1 reference

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The growing complexity of platelet aggregation

29 September 2017

1 reference

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Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation.

29 September 2017

1 reference

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Membrane-mediated structural transitions at the cytoplasmic face during integrin activation

29 September 2017

1 reference

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Antiplatelet therapy: in search of the 'magic bullet'.

29 September 2017

1 reference

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Platelets in Inflammation and Thrombosis

29 September 2017

1 reference

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Platelets in hemostasis and thrombosis: role of integrins and their ligands.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Platelets in atherothrombosis

29 September 2017

1 reference

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CD40 signaling and plaque instability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Isolation and characterization of EMS16, a C-lectin type protein from Echis multisquamatus venom, a potent and selective inhibitor of the alpha2beta1 integrin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Integrin Activation by Dithiothreitol or Mn2 Induces a Ligand-occupied Conformation and Exposure of a Novel NH2-terminal Regulatory Site on the β1Integrin Chain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Clinical Pharmacology of Eptifibatide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Severe platelet desialylation in a patient with glycoprotein Ib/IX antibody-mediated immune thrombocytopenia and fatal pulmonary hemorrhage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Cadherin 6 has a functional role in platelet aggregation and thrombus formation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

A redox site involved in integrin activation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5056500

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression

2 June 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Immunoglobulin G4-positive plasma cell myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Platelet interleukin-1alpha drives cerebrovascular inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Structural basis for platelet antiaggregation by angiotensin II type 1 receptor antagonist losartan (DuP-753) via glycoprotein VI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Redox control of platelet aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: a meta-analysis of randomized clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Venous thromboembolism: a public health concern

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Soluble Glycoprotein VI Is Raised in the Plasma of Patients With Acute Ischemic Stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Platelet GPIIb-IIIa blockers

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1186/S12959-016-0100-6

Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp

21 January 2018

1 reference

12 December 2020

Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis

1 reference

12 December 2020

Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation

1 reference

12 December 2020

Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model

1 reference

12 December 2020

Targeting Activated Platelets and Fibrinolysis

1 reference

12 December 2020

The platelet "sugar high" in diabetes

1 reference

12 December 2020

Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis

1 reference

12 December 2020

The selective inhibition of beta 1 and beta 7 integrin-mediated lymphocyte adhesion by bacitracin

1 reference

12 December 2020

Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs

1 reference

12 December 2020

Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor

1 reference

12 December 2020

Bernard-Soulier syndrome

1 reference

12 December 2020

von Willebrand Factor Inhibition Improves Endothelial Function in Patients with Stable Angina

1 reference

12 December 2020

Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli

1 reference

12 December 2020

Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo

1 reference

12 December 2020

The physiological and pathophysiological roles of platelet CLEC-2

1 reference

12 December 2020

Vicinal thiols are required for activation of the αIIbβ3 platelet integrin

1 reference

12 December 2020

Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation

1 reference

12 December 2020

Von Willebrand Factor--A New Target for TTP Treatment?

1 reference

12 December 2020

10.1186/S12959-016-0100-6

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

26 March 2020

1048499590

0 references

Fatcat ID

release_x4yltnjdnjajvorlasikr4wxcq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/x4yltnjdnjajvorlasikr4wxcq

24 November 2022

mapped directly with Wikidata item

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27766055 AND SRC:MED&resulttype=core&format=json

26 March 2020

PubMed publication ID

27766055

2 references