The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network (Q27939267)

1 December 2016

title

The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network (English)

1 reference

Diphthine--ammonia ligase YLR143W

1 December 2016

main subject

1 reference

GOA release 2020-03-11

4

Shihui Liu

0 references

Viktor Scheidt

object named as

Viktor Scheidt

3

1 reference

ORCID Public Data File 2021

author name string

Shanow Uthman

1

0 references

Christian Bär

2

0 references

Sara ten Have

5

0 references

Flaviano Giorgini

6

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Michael J R Stark

7

0 references

Raffael Schaffrath

8

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language of work or name

English

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publication date

2013

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1 reference

Creative Commons CC0 License

1 December 2016

volume

9

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issue

2

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page(s)

e1003334

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copyright license

start time

28 February 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

cites work

Chemogenomic approach identified yeast YLR143W as diphthamide synthetase

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Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4

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YBR246W is required for the third step of diphthamide biosynthesis

20 March 2017

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Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.

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Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

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Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development

20 March 2017

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20 March 2017

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Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance

20 March 2017

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20 March 2017

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Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2

20 March 2017

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Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

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20 March 2017

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20 March 2017

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20 March 2017

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DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae

20 March 2017

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A dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin A and diphtheria toxin

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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29 September 2017

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29 September 2017

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Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2.

29 September 2017

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Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae

29 September 2017

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29 September 2017

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2 June 2018

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An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.

2 June 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1003334

The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1003334

The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A.

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1003334

Purification and crystallization of the yeast elongation factor eEF2.

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1003334

Ty1 retrotransposition and programmed 1 ribosomal frameshifting require the integrity of the protein synthetic translocation step

21 January 2018

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Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2

21 January 2018

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12 December 2020

Biosynthetic labeling of diphthamide in Saccharomyces cerevisiae

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12 December 2020

Elongation factor 2 mutants deficient in diphthamide formation show temperature-sensitive cell growth

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12 December 2020

Elongation Factor 2 as a Novel Target for Selective Inhibition of Fungal Protein Synthesis

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12 December 2020

Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid

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12 December 2020

Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2

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12 December 2020

Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex

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12 December 2020

10.1371/JOURNAL.PGEN.1003334

Identifiers

DOI

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PMC publication ID

3585130

0 references

1 reference