Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution (Q27936235)

1 December 2016

title

Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution (English)

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cryogenic electron microscopy

1 December 2016

main subject

Saccharomyces cerevisiae

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Elongation factor 2 YOR133W

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GOA release 2020-03-11

author name string

M G Gomez-Lorenzo

1

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C M Spahn

2

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R K Agrawal

3

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R A Grassucci

4

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P Penczek

5

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K Chakraburtty

6

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J P Ballesta

7

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J L Lavandera

8

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J F Garcia-Bustos

9

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J Frank

10

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language of work or name

English

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publication date

1 June 2000

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1 reference

Solution structure of the E. coli 70S ribosome at 11.5 A resolution

1 December 2016

volume

19

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issue

11

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page(s)

2710-8

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cites work

1 reference

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X-ray crystal structures of 70S ribosome functional complexes

20 March 2017

1 reference

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Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit

20 March 2017

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Structure of a bacterial 30S ribosomal subunit at 5.5 A resolution

20 March 2017

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The GTPase center protein L12 is required for correct ribosomal stalk assembly but not for Saccharomyces cerevisiae viability

20 March 2017

1 reference

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Ribosomal protein P0, contrary to phosphoproteins P1 and P2, is required for ribosome activity and Saccharomyces cerevisiae viability

20 March 2017

1 reference

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Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus

20 March 2017

1 reference

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The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog

20 March 2017

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The GTPase superfamily: conserved structure and molecular mechanism

20 March 2017

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The economics of ribosome biosynthesis in yeast

20 March 2017

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Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts

20 March 2017

1 reference

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Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Dynamics of translation on the ribosome: molecular mechanics of translocation

20 March 2017

1 reference

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Translation elongation factor 2 is part of the target for a new family of antifungals

29 September 2017

1 reference

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Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

The 80S rat liver ribosome at 25 A resolution by electron cryomicroscopy and angular reconstitution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Three-dimensional structure of the yeast ribosome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

A complex profile of protein elongation: translating chemical energy into molecular movement

29 September 2017

1 reference

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A model of the translational apparatus based on a three-dimensional reconstruction of the Escherichia coli ribosome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

A functional site of the GTPase-associated center within 28S ribosomal RNA probed with an anti-RNA autoantibody

29 September 2017

1 reference

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Replacement of the L11 binding region within E.coli 23S ribosomal RNA with its homologue from yeast: in vivo and in vitro analysis of hybrid ribosomes altered in the GTPase centre

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Ribosomal Acidic Phosphoproteins P1 and P2 Are Not Required for Cell Viability but Regulate the Pattern of Protein Expression in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Electron microscopy and computer image averaging of ice-embedded large ribosomal subunits from Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

The conserved GTPase center and variable region V9 from Saccharomyces cerevisiae 26S rRNA can be replaced by their equivalents from other prokaryotes or eukaryotes without detectable loss of ribosomal function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Ribotoxin recognition of ribosomal RNA and a proposal for the mechanism of translocation

29 September 2017

1 reference

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Structure and phosphorylation of an acidic protein from 60S ribosomes and its involvement in elongation factor-2 dependent GTP hydrolysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

A ribosome-dependent GTPase from yeast distinct from elongation factor 2

29 September 2017

1 reference

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Direct three-dimensional localization and positive identification of RNA helices within the ribosome by means of genetic tagging and cryo-electron microscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Ribosomal P-protein stalk function is targeted by sordarin antifungals.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Escherichia coli 70 S ribosome at 15 A resolution by cryo-electron microscopy: localization of fMet-tRNAfMet and fitting of L1 protein

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

The ribosome at improved resolution: new techniques for merging and orientation refinement in 3D cryo-electron microscopy of biological particles

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Mutations in the elongation factor 2 gene which confer resistance to diphtheria toxin and Pseudomonas exotoxin A. Genetic and biochemical analyses

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Evidence that the G2661 region of 23S rRNA is located at the ribosomal binding sites of both elongation factors.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

The acidic ribosomal proteins as regulators of the eukaryotic ribosomal activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Mutations in ribosomal protein L10e confer resistance to the fungal-specific eukaryotic elongation factor 2 inhibitor sordarin.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Correlation of the expansion segments in mammalian rRNA with the fine structure of the 80 S ribosome; a cryoelectron microscopic reconstruction of the rabbit reticulocyte ribosome at 21 A resolution.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Mapping the Position of Translational Elongation Factor EF-G in the Ribosome by Directed Hydroxyl Radical Probing

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Visualization of elongation factor Tu on the Escherichia coli ribosome.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=212750

Cross-linking of elongation factor 2 to rat-liver ribosomal proteins by 2-iminothiolane

27 November 2018

1 reference

12 December 2020

The Elongation Factor 3 Unique in Higher Fungi and Essential for Protein Biosynthesis Is an E Site Factor

1 reference

12 December 2020

Structure of keyhole limpet hemocyanin type 1 (KLH1) at 15 Å resolution by electron cryomicroscopy and angular reconstitution † 1 †This article is dedicated to the memory of Anneke van Heel. 1Edited by M.F. Moody

1 reference

12 December 2020

Elongation Factor 2 as a Novel Target for Selective Inhibition of Fungal Protein Synthesis

1 reference

12 December 2020

Domain IV of elongation factor G from Thermus thermophilus is strictly required for translocation

1 reference

12 December 2020

Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2

1 reference

12 December 2020

Protein synthesis in yeast. I. Purification and properties of elongation factor 3 from Saccharomyces cerevisiae

1 reference

12 December 2020

Monoclonal antibodies against acidic phosphoproteins P0, P1, and P2 of eukaryotic ribosomes as functional probes

1 reference

12 December 2020

Interaction sites of ribosome-bound eukaryotic elongation factor 2 in 18S and 28S rRNA

1 reference

12 December 2020

Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid

1 reference

12 December 2020

Replacement of L7/L12.L10 protein complex in Escherichia coli ribosomes with the eukaryotic counterpart changes the specificity of elongation factor binding

1 reference

12 December 2020

Isolation and Characterisation of an Antifungal Antibiotic (GR135402) with Protein Synthesis Inhibition.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.51.41

Identifiers

DOI

10.1093/EMBOJ/19.11.2710

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PMC publication ID

212750

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1 reference