Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. (Q27852553)

13 November 2016

title

Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. (English)

1 reference

PubMed

PubMed publication ID

13 November 2016

26

0 references

Terry Van Dyke

23

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author name string

Annette O Walter

1

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Robert Tjin Tham Sjin

2

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Henry J Haringsma

3

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Kadoaki Ohashi

4

0 references

Jing Sun

5

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Kwangho Lee

6

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Aleksandr Dubrovskiy

7

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Matthew Labenski

8

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Zhendong Zhu

9

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Zhigang Wang

10

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Michael Sheets

11

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Thia St Martin

12

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Russell Karp

13

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Dan van Kalken

14

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Prasoon Chaturvedi

15

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Deqiang Niu

16

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Mariana Nacht

17

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Russell C Petter

18

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William Westlin

19

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Kevin Lin

20

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Sarah Jaw-Tsai

21

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Mitch Raponi

22

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Jeff Etter

24

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Zoe Weaver

25

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Juswinder Singh

27

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Andrew D Simmons

28

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Thomas C Harding

29

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Andrew Allen

Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers

30

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publication date

December 2013

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1 reference

3

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issue

12

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page(s)

1404-15

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cites work

1 reference

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20 March 2017

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Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

20 March 2017

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Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

20 March 2017

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Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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A quantitative analysis of kinase inhibitor selectivity

20 March 2017

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20 March 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Noncovalent wild-type-sparing inhibitors of EGFR T790M

29 September 2017

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Resistance to irreversible EGF receptor tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway

29 September 2017

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An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

29 September 2017

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HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation

29 September 2017

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29 September 2017

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Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial

29 September 2017

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The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor

29 September 2017

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Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling

29 September 2017

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MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

29 September 2017

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Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.

29 September 2017

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29 September 2017

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Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Ligand-induced activation of A431 cell epidermal growth factor receptors occurs primarily by an autocrine pathway that acts upon receptors on the surface rather than intracellularly

2 June 2018

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Biomarker Analyses and Final Overall Survival Results From a Phase III, Randomized, Open-Label, First-Line Study of Gefitinib Versus Carboplatin/Paclitaxel in Clinically Selected Patients With Advanced Non–Small-Cell Lung Cancer in Asia (IPASS)

2 June 2018

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Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer

27 November 2018

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R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer

27 November 2018

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Dermatologic Side Effects Associated with Gefitinib Therapy: Clinical Experience and Management

27 November 2018

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